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- W2995981476 abstract "Individuals are exposed to a wide range of environmental factors of different nature, social, physical, and chemical over their lifetime. The cumulative effect of these environmental stressors, their interaction with genetic factors and key susceptible developmental stages determines disease risks. The concept of the “exposome”—representing all non-genetic exposures experienced during the life course—was a call to complement the impressive advances made in measuring the human genome with similar technology investment in measuring the environmental component of disease aetiology (Wild, Cancer Epidemiol Biomark Prev 14:1847–1850, 2005). While measuring the exposome is recognized to be extremely challenging due to its dynamic, heterogeneous, and still unknown nature, advances in new and emerging technologies were seen as opportunities to characterize internal and external domains of the exposome in a more holistic way. More than a decade after the exposome concept was first proposed, several projects across Europe and the USA have started implementing at least part of it. This chapter will describe the utility of the exposome concept, its characteristics, how it can be feasibly measured, and its first implementation in health studies, focusing on the early-life periods. Finally, the challenges and future perspectives of exposome research will be presented." @default.
- W2995981476 created "2019-12-26" @default.
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- W2995981476 date "2019-12-14" @default.
- W2995981476 modified "2023-09-23" @default.
- W2995981476 title "Exposomics: The Exposome in Early Life" @default.
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- W2995981476 doi "https://doi.org/10.1007/978-981-15-0520-1_18" @default.
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