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- W2995982522 abstract "Summary As a rapidly progressing field in oncology, the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors (CARs) has shown striking efficacy in the management of hematological malignancies and has been reported in a number of clinical trials. Of note, CAR T cell therapy has shown extraordinary potential, especially in relapsed/refractory patients. However, there are still challenges regarding the further development of this strategy, spanning from engineering and manufacturing issues, to limited applications, to accompanying toxicities. In this review, we will summarize the general knowledge of this novel method, including receptor composition, applications, adverse events and challenges. Additionally, we will propose several comprehensive recommendations." @default.
- W2995982522 created "2019-12-26" @default.
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- W2995982522 date "2019-12-01" @default.
- W2995982522 modified "2023-10-17" @default.
- W2995982522 title "CAR T Cell Therapy for Hematological Malignancies" @default.
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- W2995982522 doi "https://doi.org/10.1007/s11596-019-2118-z" @default.
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