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• W2995986078 endingPage "20192529" @default.
• W2995986078 startingPage "20192529" @default.
• W2995986078 abstract "Understanding the pleiotropic consequences of gene drive systems on host fitness is essential to predict their spread through a host population. Here, we study sex-ratio (SR) X-chromosome drive in the fly Drosophila recens , where SR causes the death of Y-bearing sperm in male carriers. SR males only sire daughters, which all carry SR, thus giving the chromosome a transmission advantage. The prevalence of the SR chromosome appears stable, suggesting pleiotropic costs. It was previously shown that females homozygous for SR are sterile, and here, we test for additional fitness costs of SR. We found that females heterozygous for SR have reduced fecundity and that male SR carriers have reduced fertility in conditions of sperm competition. We then use our fitness estimates to parametrize theoretical models of SR drive and show that the decrease in fecundity and sperm competition performance can account for the observed prevalence of SR in natural populations. In addition, we found that the expected equilibrium frequency of the SR chromosome is particularly sensitive to the degree of multiple mating and performance in sperm competition. Together, our data suggest that the mating system of the organism should be carefully considered during the development of gene drive systems." @default.
• W2995986078 created "2019-12-26" @default.
• W2995986078 creator A5024586091 @default.
• W2995986078 creator A5048410492 @default.
• W2995986078 date "2019-12-18" @default.
• W2995986078 modified "2023-10-18" @default.
• W2995986078 title "Fitness consequences of a non-recombining<i>sex-ratio</i>drive chromosome can explain its prevalence in the wild" @default.
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• W2995986078 doi "https://doi.org/10.1098/rspb.2019.2529" @default.
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