FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996004736> ?p ?o ?g. }

• W2996004736 endingPage "80" @default.
• W2996004736 startingPage "71" @default.
• W2996004736 abstract "Recently, it is suggested that brain insulin resistance may contribute to the development of Alzheimer's disease; therefore, there is a high interest in its investigation. Streptozotocin (STZ) is often used to induce dysregulation of glucose and insulin metabolism in animal and cell culture models. Alteration in insulin sensitivity however, has not yet been assessed in neuronal cells after STZ treatment. We aimed at studying the concentration dependence of the protective effect of insulin on STZ-induced damage using SH-SY5Y cell line. Cells were treated with STZ and cell viability was assessed by resazurin reduction and lactate dehydrogenase release assays. Low serum (LS) medium was used as control damage. The effect of various concentrations (30, 100, 300, 1000 nM) of insulin was studied on cell viability and glycogen synthase kinase-3 (GSK-3) phosphorylation, an indicator of insulin signaling. STZ induced dose- and time-dependent cytotoxicity, its 1 mM concentration exerted a low, gradually developing damage. The cytoprotective effect of insulin was demonstrated in both STZ and LS groups. Its maximal effect was lower in the STZ-treated cells; however, its effective concentration remained largely unaltered. Insulin-induced GSK-3 phosphorylation was similar in the STZ- and LS-treated cells suggesting unchanged insulin signaling. Our present results indicate that STZ does not induce significant impairment in insulin sensitivity in SH-SY5Y cells, thus in this cell line it is not a good tool for studying the role of insulin resistance in neurodegeneration and to examine protective agents acting by improving insulin signaling." @default.
• W2996004736 created "2019-12-26" @default.
• W2996004736 creator A5028566172 @default.
• W2996004736 creator A5029121781 @default.
• W2996004736 creator A5036112889 @default.
• W2996004736 creator A5040446299 @default.
• W2996004736 creator A5062387891 @default.
• W2996004736 creator A5066875827 @default.
• W2996004736 date "2019-12-19" @default.
• W2996004736 modified "2023-10-13" @default.
• W2996004736 title "Lack of insulin resistance in response to streptozotocin treatment in neuronal SH-SY5Y cell line" @default.
• W2996004736 cites W1500350553 @default.
• W2996004736 cites W1516559507 @default.
• W2996004736 cites W1528865376 @default.
• W2996004736 cites W1543788907 @default.
• W2996004736 cites W1567624342 @default.
• W2996004736 cites W1874453010 @default.
• W2996004736 cites W1990861932 @default.
• W2996004736 cites W1993174592 @default.
• W2996004736 cites W1999366133 @default.
• W2996004736 cites W2003151324 @default.
• W2996004736 cites W2003776455 @default.
• W2996004736 cites W2005299560 @default.
• W2996004736 cites W2008904654 @default.
• W2996004736 cites W2010357177 @default.
• W2996004736 cites W2019796742 @default.
• W2996004736 cites W2022153484 @default.
• W2996004736 cites W2033893668 @default.
• W2996004736 cites W2035825704 @default.
• W2996004736 cites W2043381283 @default.
• W2996004736 cites W2044484832 @default.
• W2996004736 cites W2053625921 @default.
• W2996004736 cites W2059549393 @default.
• W2996004736 cites W2060085753 @default.
• W2996004736 cites W2066468311 @default.
• W2996004736 cites W2070290955 @default.
• W2996004736 cites W2073012903 @default.
• W2996004736 cites W2080512251 @default.
• W2996004736 cites W2080807247 @default.
• W2996004736 cites W2087443596 @default.
• W2996004736 cites W2091186163 @default.
• W2996004736 cites W2092632809 @default.
• W2996004736 cites W2097157695 @default.
• W2996004736 cites W2101187328 @default.
• W2996004736 cites W2101846365 @default.
• W2996004736 cites W2114022129 @default.
• W2996004736 cites W2128635872 @default.
• W2996004736 cites W2144049791 @default.
• W2996004736 cites W2171272231 @default.
• W2996004736 cites W2189797710 @default.
• W2996004736 cites W2197148295 @default.
• W2996004736 cites W2213727944 @default.
• W2996004736 cites W2330104828 @default.
• W2996004736 cites W2497601590 @default.
• W2996004736 cites W2511920920 @default.
• W2996004736 cites W2531062701 @default.
• W2996004736 cites W2567876820 @default.
• W2996004736 cites W2616327140 @default.
• W2996004736 cites W2623583708 @default.
• W2996004736 cites W2752896879 @default.
• W2996004736 cites W2769468932 @default.
• W2996004736 cites W2795660725 @default.
• W2996004736 cites W2800916556 @default.
• W2996004736 cites W2804179356 @default.
• W2996004736 cites W2920939004 @default.
• W2996004736 cites W2976197289 @default.
• W2996004736 cites W3193194219 @default.
• W2996004736 doi "https://doi.org/10.1007/s00702-019-02118-5" @default.
• W2996004736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6942577" @default.
• W2996004736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31858268" @default.
• W2996004736 hasPublicationYear "2019" @default.
• W2996004736 type Work @default.
• W2996004736 sameAs 2996004736 @default.
• W2996004736 citedByCount "8" @default.
• W2996004736 countsByYear W29960047362021 @default.
• W2996004736 countsByYear W29960047362022 @default.
• W2996004736 countsByYear W29960047362023 @default.
• W2996004736 crossrefType "journal-article" @default.
• W2996004736 hasAuthorship W2996004736A5028566172 @default.
• W2996004736 hasAuthorship W2996004736A5029121781 @default.
• W2996004736 hasAuthorship W2996004736A5036112889 @default.
• W2996004736 hasAuthorship W2996004736A5040446299 @default.
• W2996004736 hasAuthorship W2996004736A5062387891 @default.
• W2996004736 hasAuthorship W2996004736A5066875827 @default.
• W2996004736 hasBestOaLocation W29960047361 @default.
• W2996004736 hasConcept C112446052 @default.
• W2996004736 hasConcept C126322002 @default.
• W2996004736 hasConcept C134018914 @default.
• W2996004736 hasConcept C1491633281 @default.
• W2996004736 hasConcept C181199279 @default.
• W2996004736 hasConcept C185592680 @default.
• W2996004736 hasConcept C2776715637 @default.
• W2996004736 hasConcept C2777318727 @default.
• W2996004736 hasConcept C2777391703 @default.
• W2996004736 hasConcept C2779083432 @default.
• W2996004736 hasConcept C2779280383 @default.
• W2996004736 hasConcept C2779306644 @default.
• W2996004736 hasConcept C53227056 @default.

• next