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- W2996006892 abstract "Highly functionalised potential neuraminidase (NA) inhibitors, analogues of peramivir, were synthesised via a new and versatile method starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide derived from 2-ethylbutanal and the commercially available and inexpensive cyclopentadiene and 1,3-cyclohexadiene, which afforded the isoxazolino-cyclopentene or cyclohexene intermediates, respectively. The subsequent reaction of the C=C bond in different conditions allowed the functionalisation of the five (or six) membered carbon nucleus. Further functionalised derivatives displaying an amino and a hydroxyl group were achieved via the final opening of the isoxazoline ring." @default.
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- W2996006892 date "2019-12-12" @default.
- W2996006892 modified "2023-09-23" @default.
- W2996006892 title "New Strategy of Synthesis of Peramivir Analogues as Potential Neuraminidase Inhibitors" @default.
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- W2996006892 doi "https://doi.org/10.1055/s-0039-1690039" @default.
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