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- W2996046565 abstract "A comprehensive, multi-omic survey was performed to disclose the genetic backgrounds and differences between multidrug-resistant and -susceptible C. haemulonii strains. Genes were identified with mutations or significant expression differences in multidrug-resistant compared to multidrug-susceptible strains, which were mainly involved in multidrug resistance, stress fitness, and morphology. The Cdr1-encoding gene, C. haemulonii 2486 ( CH_2486 ), was expressed at a significantly increased level in multidrug-resistant strains. Functional inhibition experiments further implicated potential roles of CH_2486 in drug resistance. A gene spontaneously mutated in resistant strains, CH_4347 , was experimentally validated to influence the morphology of spores, possibly by controlling cell wall integrity." @default.
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- W2996046565 date "2019-12-17" @default.
- W2996046565 modified "2023-10-15" @default.
- W2996046565 title "Global Screening of Genomic and Transcriptomic Factors Associated with Phenotype Differences between Multidrug-Resistant and -Susceptible Candida haemulonii Strains" @default.
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- W2996046565 doi "https://doi.org/10.1128/msystems.00459-19" @default.
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