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• W2996049810 abstract "Abstract Cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKs) kill compromised cells to defend against tumor and viral infections. Both effector cell types use multiple strategies to induce target cell death including Fas/CD95 activation; and the release of perforin and a group of lymphocyte granule serine proteases called granzymes. Granzymes have relatively broad and overlapping substrate specificities and may hydrolyze a wide range of peptidic epitopes; it is therefore challenging to identify their natural and synthetic substrates and to distinguish their localization and functions. Here, we present a specific and potent substrate, an inhibitor, and an activity-based probe of Granzyme A (GrA) that can be used to follow functional GrA in cells." @default.
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• W2996049810 date "2019-12-10" @default.
• W2996049810 modified "2023-10-17" @default.
• W2996049810 title "Detection of active Granzyme A in NK92 cells with fluorescent activity-based probe" @default.
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• W2996049810 doi "https://doi.org/10.1101/869149" @default.
• W2996049810 hasPublicationYear "2019" @default.
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