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- W2996052089 abstract "PAH is a rare disease ultimately leading to right heart failure and death. Associations between quality of life and PAH severity are scarcely reported. The aim of this study was to address this gap. Baseline utilities were derived from completed RCTs: GRIPHON (CAMPHOR), SERAPHIN (SF-36), COMPASS-2 (EQ-5D) and EARLY (CAMPHOR and SF-36). Utilities were compared across categories (defined in the 2015 ESC/ERS Guidelines) by 6MWD, WHO FC and NT-proBNP which describe disease severity. Median (Q1, Q3) utilities by 6MWD category (<165, 165-440, >440 m) were: 0.30 (0.28, 0.40), 0.67 (0.45, 0.96), 0.89 (0.52, 0.96) in GRIPHON; 0.52 (0.43, 0.57), 0.61 (0.54, 0.68), 0.67 (0.62, 0.73) in SERAPHIN and 0.74 (0.74, 0.74), 0.69 (0.62, 0.81), 0.71 (0.62, 0.88) in COMPASS-2. No patients had 6MWD <165 m in EARLY. Utilities in EARLY were 0.64 (0.39, 0.76), 0.96 (0.82, 0.96) using CAMPHOR and 0.65 (0.61, 0.77), 0.69 (0.63, 0.79) using SF-36 for the 165-440 m and the >440 m categories respectively. Median (Q1, Q3) utilities by WHO FC II, III and IV were: 0.82 (0.52, 0.96), 0.61 (0.32, 0.82), 0.32 ( 0.30, 0.36) in GRIPHON; 0.65 (0.58, 0.72), 0.60 (0.53, 0.66), 0.53 (0.44, 0.68) in SERAPHIN and 0.76 (0.69, 0.88), 0.69 (0.59, 0.80), -0.13 (-0.25, -0.02) in COMPASS-2. In EARLY all the patients were in WHO FC II and the calculated median utility was 0.74 (0.52, 0.96) using CAMPHOR and 0.68 (0.61, 0.77) using SF-36. Median utilities by NT-proBNP category (< 300, 300-1400, >1400 ng/L) ranged from 0.61 to 0.76, in GRIPHON; 0.69 to 0.72 in COMPASS-2; 0.64 to 0.74 using CAMPHOR and 0.64 to 0.72 using SF-36 in EARLY. At baseline high utilities appear to be associated with high 6MWD (>440 m) and low WHO FC (I or II). There is no clear trend in the association between utilities and NT-proBNP." @default.
- W2996052089 created "2019-12-26" @default.
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- W2996052089 date "2019-11-01" @default.
- W2996052089 modified "2023-09-27" @default.
- W2996052089 title "PRO133 ASSOCIATION BETWEEN HEALTH-RELATED QUALITY OF LIFE AND PULMONARY ARTERIAL HYPERTENSION (PAH) DISEASE SEVERITY: A REVIEW OF GRIPHON, SERAPHIN, COMPASS-2 AND EARLY TRIALS" @default.
- W2996052089 doi "https://doi.org/10.1016/j.jval.2019.09.2462" @default.
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