Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996077660> ?p ?o ?g. }
- W2996077660 endingPage "107440" @default.
- W2996077660 startingPage "107440" @default.
- W2996077660 abstract "Pulsed electric fields (PEFs) can be used to transiently increase cell membrane permeability in procedures ranging from gene therapy to tumor eradication. Although very efficient, PEF-based therapies generally require the use of invasive electrodes, which cause pain and tissue damage. An emerging noninvasive, contactless alternative to PEFs are High Intensity Pulsed Electromagnetic Fields (HI-PEMF), whereby the electric field inside the tissue is induced remotely by external pulsed magnetic field. However, one of the current major drawbacks of HI-PEMFs is their inferior efficiency compared to PEFs. In this study we present the proof-of-concept that by adding highly conductive 5 and 20 nm gold nanoparticles (Au NPs), we can significantly potentiate the permeabilizing effect of HI-PEMFs, making it possible to permeabilize up to 80% of the cells with minimal or no effect on cell survival, compared to negligible percentage of permeabilized cells using HI-PEMF alone. Experiments, conducted on Chinese Hamster Ovary cells and Escherichia coli, suggest that Au NPs act as distributed nanoelectrodes, locally enhancing the electric field induced at the plasma membrane. Our findings open up an avenue of possibilities for combining naked as well as functionalized Au NPs with HI-PEMFs for noninvasive, remotely controlled smart drug delivery applications." @default.
- W2996077660 created "2019-12-26" @default.
- W2996077660 creator A5013167358 @default.
- W2996077660 creator A5017469292 @default.
- W2996077660 creator A5028357334 @default.
- W2996077660 creator A5043966778 @default.
- W2996077660 creator A5044904536 @default.
- W2996077660 creator A5056004786 @default.
- W2996077660 creator A5062367378 @default.
- W2996077660 creator A5071211846 @default.
- W2996077660 date "2020-04-01" @default.
- W2996077660 modified "2023-10-17" @default.
- W2996077660 title "Contactless electroporation induced by high intensity pulsed electromagnetic fields via distributed nanoelectrodes" @default.
- W2996077660 cites W1588755775 @default.
- W2996077660 cites W1597938223 @default.
- W2996077660 cites W1884663465 @default.
- W2996077660 cites W1968762869 @default.
- W2996077660 cites W1988412655 @default.
- W2996077660 cites W2008110015 @default.
- W2996077660 cites W2009829156 @default.
- W2996077660 cites W2011705292 @default.
- W2996077660 cites W2013594992 @default.
- W2996077660 cites W2023304098 @default.
- W2996077660 cites W2032132376 @default.
- W2996077660 cites W2032311570 @default.
- W2996077660 cites W2034395013 @default.
- W2996077660 cites W2036004272 @default.
- W2996077660 cites W2036597256 @default.
- W2996077660 cites W2060688826 @default.
- W2996077660 cites W2065135664 @default.
- W2996077660 cites W2082781273 @default.
- W2996077660 cites W2084427952 @default.
- W2996077660 cites W2093711343 @default.
- W2996077660 cites W2097107348 @default.
- W2996077660 cites W2122751535 @default.
- W2996077660 cites W2125196414 @default.
- W2996077660 cites W2140332412 @default.
- W2996077660 cites W2153198919 @default.
- W2996077660 cites W2153454550 @default.
- W2996077660 cites W2172271530 @default.
- W2996077660 cites W2182179137 @default.
- W2996077660 cites W2186342673 @default.
- W2996077660 cites W2210420615 @default.
- W2996077660 cites W2256821739 @default.
- W2996077660 cites W2292137950 @default.
- W2996077660 cites W2407145072 @default.
- W2996077660 cites W2410301788 @default.
- W2996077660 cites W2465467626 @default.
- W2996077660 cites W2470026303 @default.
- W2996077660 cites W2519956243 @default.
- W2996077660 cites W2552214854 @default.
- W2996077660 cites W2554550106 @default.
- W2996077660 cites W2565743177 @default.
- W2996077660 cites W2574492937 @default.
- W2996077660 cites W2589978742 @default.
- W2996077660 cites W2608448109 @default.
- W2996077660 cites W2741112276 @default.
- W2996077660 cites W2750906583 @default.
- W2996077660 cites W2805267068 @default.
- W2996077660 cites W2917550741 @default.
- W2996077660 cites W2962024039 @default.
- W2996077660 cites W2969776795 @default.
- W2996077660 doi "https://doi.org/10.1016/j.bioelechem.2019.107440" @default.
- W2996077660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31869699" @default.
- W2996077660 hasPublicationYear "2020" @default.
- W2996077660 type Work @default.
- W2996077660 sameAs 2996077660 @default.
- W2996077660 citedByCount "22" @default.
- W2996077660 countsByYear W29960776602020 @default.
- W2996077660 countsByYear W29960776602021 @default.
- W2996077660 countsByYear W29960776602022 @default.
- W2996077660 countsByYear W29960776602023 @default.
- W2996077660 crossrefType "journal-article" @default.
- W2996077660 hasAuthorship W2996077660A5013167358 @default.
- W2996077660 hasAuthorship W2996077660A5017469292 @default.
- W2996077660 hasAuthorship W2996077660A5028357334 @default.
- W2996077660 hasAuthorship W2996077660A5043966778 @default.
- W2996077660 hasAuthorship W2996077660A5044904536 @default.
- W2996077660 hasAuthorship W2996077660A5056004786 @default.
- W2996077660 hasAuthorship W2996077660A5062367378 @default.
- W2996077660 hasAuthorship W2996077660A5071211846 @default.
- W2996077660 hasBestOaLocation W29960776601 @default.
- W2996077660 hasConcept C104317684 @default.
- W2996077660 hasConcept C121332964 @default.
- W2996077660 hasConcept C12554922 @default.
- W2996077660 hasConcept C136229726 @default.
- W2996077660 hasConcept C170493617 @default.
- W2996077660 hasConcept C171250308 @default.
- W2996077660 hasConcept C175656101 @default.
- W2996077660 hasConcept C185592680 @default.
- W2996077660 hasConcept C186852380 @default.
- W2996077660 hasConcept C192562407 @default.
- W2996077660 hasConcept C41625074 @default.
- W2996077660 hasConcept C55493867 @default.
- W2996077660 hasConcept C60799052 @default.
- W2996077660 hasConcept C62520636 @default.
- W2996077660 hasConcept C71924100 @default.
- W2996077660 hasConcept C86803240 @default.