FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996078736> ?p ?o ?g. }

• W2996078736 abstract "Abstract Background The role of meteorin ( METRN ) in colorectal cancer has not been reported previously. We aimed to explore the relationship between METRN and colorectal cancer (CRC) prognosis. Methods Data were retrieved from the Gene Expression Omnibus database. Gene expression values were log2 transformed and normalized by quantile normalization. Missing values were imputed with the R impute package. Differentially expressed genes were analyzed using the R limma package. METRN expression was compared between normal and CRC tissues and among different stages and subtypes of CRC. We assessed the relationship between METRN and KRAS/BRAF mutations in CRC. Five‐year overall (OS), disease‐free (DFS), and disease‐specific survival (DSS) rates were determined by Kaplan–Meier analysis and analyzed by log‐rank test. Results METRN was expressed at a higher level in CRC ( p = .0011) than in normal tissues, especially in advanced stages ( p = .0343). METRN expression levels were higher in the MSI (dMMR) subtype ( p < .001) and usually with BRAF mutations ( p < .0001). METRN overexpression was associated with poor prognosis and low OS ( p = .01014), DFS ( p = .0146), and DSS ( p < .0001) rates. Conclusion METRN overexpression is a predictive factor for poor prognosis in patients with CRC." @default.
• W2996078736 created "2019-12-26" @default.
• W2996078736 creator A5001234998 @default.
• W2996078736 creator A5035305169 @default.
• W2996078736 creator A5056069816 @default.
• W2996078736 creator A5072438589 @default.
• W2996078736 date "2019-12-20" @default.
• W2996078736 modified "2023-09-27" @default.
• W2996078736 title "Over expression of <i>METRN</i> predicts poor clinical prognosis in colorectal cancer" @default.
• W2996078736 cites W1576527279 @default.
• W2996078736 cites W1597604324 @default.
• W2996078736 cites W1966467502 @default.
• W2996078736 cites W1970637701 @default.
• W2996078736 cites W1971784882 @default.
• W2996078736 cites W1979721476 @default.
• W2996078736 cites W2001871616 @default.
• W2996078736 cites W2009637450 @default.
• W2996078736 cites W2016145525 @default.
• W2996078736 cites W2069443403 @default.
• W2996078736 cites W2081961138 @default.
• W2996078736 cites W2084469088 @default.
• W2996078736 cites W2113668642 @default.
• W2996078736 cites W2115899284 @default.
• W2996078736 cites W2123636561 @default.
• W2996078736 cites W2130921932 @default.
• W2996078736 cites W2168680994 @default.
• W2996078736 cites W2236134270 @default.
• W2996078736 cites W2273001900 @default.
• W2996078736 cites W2465256972 @default.
• W2996078736 cites W2614162828 @default.
• W2996078736 cites W2736345028 @default.
• W2996078736 cites W2787553551 @default.
• W2996078736 cites W2890380917 @default.
• W2996078736 cites W2898642883 @default.
• W2996078736 cites W2911032670 @default.
• W2996078736 cites W2915337547 @default.
• W2996078736 cites W2924650435 @default.
• W2996078736 cites W2953517735 @default.
• W2996078736 cites W2954128874 @default.
• W2996078736 cites W2968806891 @default.
• W2996078736 cites W31576990 @default.
• W2996078736 doi "https://doi.org/10.1002/mgg3.1102" @default.
• W2996078736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7057108" @default.
• W2996078736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31859449" @default.
• W2996078736 hasPublicationYear "2019" @default.
• W2996078736 type Work @default.
• W2996078736 sameAs 2996078736 @default.
• W2996078736 citedByCount "4" @default.
• W2996078736 countsByYear W29960787362020 @default.
• W2996078736 countsByYear W29960787362021 @default.
• W2996078736 countsByYear W29960787362022 @default.
• W2996078736 crossrefType "journal-article" @default.
• W2996078736 hasAuthorship W2996078736A5001234998 @default.
• W2996078736 hasAuthorship W2996078736A5035305169 @default.
• W2996078736 hasAuthorship W2996078736A5056069816 @default.
• W2996078736 hasAuthorship W2996078736A5072438589 @default.
• W2996078736 hasBestOaLocation W29960787361 @default.
• W2996078736 hasConcept C10515644 @default.
• W2996078736 hasConcept C121608353 @default.
• W2996078736 hasConcept C126322002 @default.
• W2996078736 hasConcept C143998085 @default.
• W2996078736 hasConcept C2779134260 @default.
• W2996078736 hasConcept C2781187634 @default.
• W2996078736 hasConcept C3019894029 @default.
• W2996078736 hasConcept C502942594 @default.
• W2996078736 hasConcept C526805850 @default.
• W2996078736 hasConcept C66339696 @default.
• W2996078736 hasConcept C71924100 @default.
• W2996078736 hasConceptScore W2996078736C10515644 @default.
• W2996078736 hasConceptScore W2996078736C121608353 @default.
• W2996078736 hasConceptScore W2996078736C126322002 @default.
• W2996078736 hasConceptScore W2996078736C143998085 @default.
• W2996078736 hasConceptScore W2996078736C2779134260 @default.
• W2996078736 hasConceptScore W2996078736C2781187634 @default.
• W2996078736 hasConceptScore W2996078736C3019894029 @default.
• W2996078736 hasConceptScore W2996078736C502942594 @default.
• W2996078736 hasConceptScore W2996078736C526805850 @default.
• W2996078736 hasConceptScore W2996078736C66339696 @default.
• W2996078736 hasConceptScore W2996078736C71924100 @default.
• W2996078736 hasFunder F4320322999 @default.
• W2996078736 hasIssue "3" @default.
• W2996078736 hasLocation W29960787361 @default.
• W2996078736 hasLocation W29960787362 @default.
• W2996078736 hasLocation W29960787363 @default.
• W2996078736 hasOpenAccess W2996078736 @default.
• W2996078736 hasPrimaryLocation W29960787361 @default.
• W2996078736 hasRelatedWork W2049754458 @default.
• W2996078736 hasRelatedWork W2165566097 @default.
• W2996078736 hasRelatedWork W2350493697 @default.
• W2996078736 hasRelatedWork W2435704186 @default.
• W2996078736 hasRelatedWork W2985060949 @default.
• W2996078736 hasRelatedWork W3000288349 @default.
• W2996078736 hasRelatedWork W3026015583 @default.
• W2996078736 hasRelatedWork W3043837606 @default.
• W2996078736 hasRelatedWork W4386087407 @default.
• W2996078736 hasRelatedWork W2588285805 @default.
• W2996078736 hasVolume "8" @default.
• W2996078736 isParatext "false" @default.
• W2996078736 isRetracted "false" @default.
• W2996078736 magId "2996078736" @default.

• next