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- W2996087839 abstract "N-Octyl-β-valienamine (NOV) 1 and N-octyl-4-epi-β-valienamine (NOEV) 2 are potent chemical chaperone drug candidates for the therapy of lysosomal storage disorders. Novel stereoselective syntheses of NOV 1 and NOEV 2 starting from naturally abundant (-)-shikimic acid are described in this article. The common key intermediate compound 5 was first synthesized from readily available (-)-shikimic acid via 9 steps in 50% yield. Compound 5 was then converted to NOV 1via 5 steps in 61% yield, and it was also converted to NOEV 2via 8 steps in 38% yield. In summary, NOV 1 was synthesized via 14 steps in 31% overall yield; and NOEV 2 was synthesized via 17 steps in 19% overall yield." @default.
- W2996087839 created "2019-12-26" @default.
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- W2996087839 date "2019-01-01" @default.
- W2996087839 modified "2023-09-26" @default.
- W2996087839 title "Novel stereoselective syntheses of <i>N</i>-octyl-β-valienamine (NOV) and <i>N</i>-octyl-4-<i>epi</i>-β-valienamine (NOEV) from (−)-shikimic acid" @default.
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- W2996087839 doi "https://doi.org/10.1039/c9ra09235h" @default.
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