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• W2996120645 abstract "Cervical cancer is a common gynecological malignancy with high morbidity worldwide. MicroRNAs (miRNAs) serve critical roles in cervical cancer progression. Accumulating evidence indicates that miR-873 functions as a tumor suppressor in certain types of cancer. However, the function and mechanism of miR-873 in the progression of cervical cancer have not been completely elucidated. In the present study, the role and mechanism of miR-873 in the proliferation, migration and invasion of cervical cancer cells were investigated. miR-873 expression was markedly decreased in cervical cancer, while glioma-associated oncogene homolog 1 (GLI1) was found to be a direct target of miR-873 by conducting dual-luciferase reporter assays. Furthermore, miR-873 overexpression reduced the expression of GLI1, and decreased the proliferation, metastasis and epithelial-mesenchymal transition of cancer cells. In rescue experiments, overexpression of GLI1 in cervical cancer cells effectively reversed the inhibitory effect induced by miR-873 mimics. Therefore, the results of the present study suggested that miR-873 functions as a tumor suppressor miRNA, and future studies should address its potential application in the treatment of cervical cancer." @default.
• W2996120645 created "2019-12-26" @default.
• W2996120645 creator A5061976160 @default.
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• W2996120645 date "2019-12-18" @default.
• W2996120645 modified "2023-09-24" @default.
• W2996120645 title "MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1" @default.
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• W2996120645 doi "https://doi.org/10.3892/etm.2019.8348" @default.
• W2996120645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966164" @default.
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