Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996131471> ?p ?o ?g. }
- W2996131471 endingPage "669" @default.
- W2996131471 startingPage "669" @default.
- W2996131471 abstract "The transient receptor potential akyrin type-1 (TRPA1) is a non-selective cation channel playing a pivotal role in pain sensation and neurogenic inflammation. TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert oxaliplatin-induced neuropathic pain and inflammatory trigeminal allodynia. In this context, aiming at developing drugs that are able to target TRPA1 channels in the CNS and promote an antioxidant effect, permeability across the blood–brain barrier (BBB) represents a central issue. Niosomes are nanovesicles that can be functionalized with specific ligands selectively recognized by transporters expressed on the BBB. In this work, the activity of ADM_09 on neocortex cultures was studied, and an efficient formulation to cross the BBB was developed with the aim of increasing the concentration of ADM_09 into the brain and selectively delivering it to the CNS rapidly after parenteral administration." @default.
- W2996131471 created "2019-12-26" @default.
- W2996131471 creator A5008224712 @default.
- W2996131471 creator A5025289089 @default.
- W2996131471 creator A5025352148 @default.
- W2996131471 creator A5037347728 @default.
- W2996131471 creator A5040495445 @default.
- W2996131471 creator A5041901658 @default.
- W2996131471 creator A5045166586 @default.
- W2996131471 creator A5059017463 @default.
- W2996131471 creator A5066280195 @default.
- W2996131471 creator A5070522238 @default.
- W2996131471 creator A5074112445 @default.
- W2996131471 creator A5083113704 @default.
- W2996131471 date "2019-12-10" @default.
- W2996131471 modified "2023-09-25" @default.
- W2996131471 title "Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain" @default.
- W2996131471 cites W1480859163 @default.
- W2996131471 cites W1526194910 @default.
- W2996131471 cites W1970780449 @default.
- W2996131471 cites W1979009614 @default.
- W2996131471 cites W1987062404 @default.
- W2996131471 cites W1989581618 @default.
- W2996131471 cites W2019989846 @default.
- W2996131471 cites W2055117699 @default.
- W2996131471 cites W2061318069 @default.
- W2996131471 cites W2107123049 @default.
- W2996131471 cites W2110651590 @default.
- W2996131471 cites W2119299183 @default.
- W2996131471 cites W2128865950 @default.
- W2996131471 cites W2145130079 @default.
- W2996131471 cites W2145376463 @default.
- W2996131471 cites W2164998622 @default.
- W2996131471 cites W2334039905 @default.
- W2996131471 cites W2340981781 @default.
- W2996131471 cites W2342921077 @default.
- W2996131471 cites W2489891688 @default.
- W2996131471 cites W2556786246 @default.
- W2996131471 cites W2605800393 @default.
- W2996131471 cites W2628274702 @default.
- W2996131471 cites W2751893154 @default.
- W2996131471 cites W2766710973 @default.
- W2996131471 cites W2768052566 @default.
- W2996131471 cites W2802447669 @default.
- W2996131471 cites W2802635838 @default.
- W2996131471 cites W2883148673 @default.
- W2996131471 cites W2885816098 @default.
- W2996131471 cites W2888193742 @default.
- W2996131471 cites W2894860181 @default.
- W2996131471 cites W2898328242 @default.
- W2996131471 cites W2929395350 @default.
- W2996131471 cites W2943887461 @default.
- W2996131471 cites W2985498837 @default.
- W2996131471 cites W4252015878 @default.
- W2996131471 doi "https://doi.org/10.3390/pharmaceutics11120669" @default.
- W2996131471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6956366" @default.
- W2996131471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31835593" @default.
- W2996131471 hasPublicationYear "2019" @default.
- W2996131471 type Work @default.
- W2996131471 sameAs 2996131471 @default.
- W2996131471 citedByCount "7" @default.
- W2996131471 countsByYear W29961314712021 @default.
- W2996131471 countsByYear W29961314712022 @default.
- W2996131471 countsByYear W29961314712023 @default.
- W2996131471 crossrefType "journal-article" @default.
- W2996131471 hasAuthorship W2996131471A5008224712 @default.
- W2996131471 hasAuthorship W2996131471A5025289089 @default.
- W2996131471 hasAuthorship W2996131471A5025352148 @default.
- W2996131471 hasAuthorship W2996131471A5037347728 @default.
- W2996131471 hasAuthorship W2996131471A5040495445 @default.
- W2996131471 hasAuthorship W2996131471A5041901658 @default.
- W2996131471 hasAuthorship W2996131471A5045166586 @default.
- W2996131471 hasAuthorship W2996131471A5059017463 @default.
- W2996131471 hasAuthorship W2996131471A5066280195 @default.
- W2996131471 hasAuthorship W2996131471A5070522238 @default.
- W2996131471 hasAuthorship W2996131471A5074112445 @default.
- W2996131471 hasAuthorship W2996131471A5083113704 @default.
- W2996131471 hasBestOaLocation W29961314711 @default.
- W2996131471 hasConcept C126322002 @default.
- W2996131471 hasConcept C150903083 @default.
- W2996131471 hasConcept C151730666 @default.
- W2996131471 hasConcept C155164980 @default.
- W2996131471 hasConcept C15744967 @default.
- W2996131471 hasConcept C169760540 @default.
- W2996131471 hasConcept C170493617 @default.
- W2996131471 hasConcept C185592680 @default.
- W2996131471 hasConcept C207001950 @default.
- W2996131471 hasConcept C25938499 @default.
- W2996131471 hasConcept C2778402981 @default.
- W2996131471 hasConcept C2779343474 @default.
- W2996131471 hasConcept C529278444 @default.
- W2996131471 hasConcept C71924100 @default.
- W2996131471 hasConcept C86803240 @default.
- W2996131471 hasConcept C98274493 @default.
- W2996131471 hasConceptScore W2996131471C126322002 @default.
- W2996131471 hasConceptScore W2996131471C150903083 @default.
- W2996131471 hasConceptScore W2996131471C151730666 @default.
- W2996131471 hasConceptScore W2996131471C155164980 @default.