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• W2996133020 startingPage "84" @default.
• W2996133020 abstract "Sensitive imaging of intracellular microRNAs (miRNAs) in cells is of great significance in clinical diagnoses and disease treatments, and it remains a major challenge to achieve this goal. Herein, we report a new in situ rolling circle transcription synchronization machinery (RCTsm) of lighting-up RNA aptamer strategy for highly sensitive imaging and selective differentiation of miRNA expression levels in cells. Such a RCTsm approach utilizes a DNA promoter to recycle the target miRNAs to trigger the initiation of multiple RCT process for the yield of many lighting-up RNA aptamers. The malachite green dye further binds these aptamers to show significantly enhanced fluorescence for completely label-free detection of the target miRNAs with a high sensitivity in vitro with a low femtomolar detection limit. More importantly, sensitive detection of under-expressed miRNAs in cells and distinct differentiation of the miRNA expression variations in different cells can also be realized with this RCTsm approach in a washing-free format, making it a versatile and useful tool for imaging trace miRNAs in single cells with the great potential for early cancer diagnosis as well as biomedical research." @default.
• W2996133020 created "2019-12-26" @default.
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• W2996133020 date "2020-03-01" @default.
• W2996133020 modified "2023-10-18" @default.
• W2996133020 title "Lighting-up RNA aptamer transcription synchronization amplification for ultrasensitive and label-free imaging of microRNA in single cells" @default.
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• W2996133020 doi "https://doi.org/10.1016/j.aca.2019.12.040" @default.
• W2996133020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32043999" @default.
• W2996133020 hasPublicationYear "2020" @default.
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