FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996164134> ?p ?o ?g. }

• W2996164134 endingPage "153" @default.
• W2996164134 startingPage "146" @default.
• W2996164134 abstract "Purpose of review The bone marrow is home to hematopoietic stem cells responsible for lifelong blood production, alongside mesenchymal stem cells required for skeletal regeneration. In the bone marrow, a unique combination of signals derived from a multitude of cell types results in the establishment of so-called niches that regulate stem-cell maintenance and differentiation. Recently, single-cell and spatially resolved transcriptomics technologies have been utilized to characterize the murine bone marrow microenvironment during homeostasis, stress and upon cancer-induced remodeling. In this review, we summarize the major findings of these studies. Recent findings Single-cell technologies applied to bone marrow provided the first systematic and label-free identification of bone marrow cell types, enabled their molecular and spatial characterization, and clarified the cellular sources of key prohematopoietic factors. Large transcriptional heterogeneity and novel subpopulations were observed in compartments previously thought to be homogenous. For example, Lepr Cxcl12-abundant reticular cells were shown to constitute the major source of prohematopoietic factors, but consist of subpopulations differing in their adipogenic versus osteogenic priming, morphology and localization. These subpopulations were suggested to act as professional cytokine secreting cells, thereby establishing distinct bone marrow niches. Summary Single-cell and spatially resolved transcriptomics approaches have clarified the molecular identity and localization of bone marrow-resident cell types, paving the road for a deeper exploration of bone marrow niches in the mouse and humans." @default.
• W2996164134 created "2019-12-26" @default.
• W2996164134 creator A5028715904 @default.
• W2996164134 creator A5033044950 @default.
• W2996164134 creator A5066859773 @default.
• W2996164134 date "2020-03-01" @default.
• W2996164134 modified "2023-10-18" @default.
• W2996164134 title "Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment" @default.
• W2996164134 cites W1751860665 @default.
• W2996164134 cites W1787222452 @default.
• W2996164134 cites W1966817158 @default.
• W2996164134 cites W1968628080 @default.
• W2996164134 cites W1979935756 @default.
• W2996164134 cites W1980052833 @default.
• W2996164134 cites W1985987855 @default.
• W2996164134 cites W2003509125 @default.
• W2996164134 cites W2005718040 @default.
• W2996164134 cites W2017907565 @default.
• W2996164134 cites W2024626836 @default.
• W2996164134 cites W2025371271 @default.
• W2996164134 cites W2038920846 @default.
• W2996164134 cites W2041357218 @default.
• W2996164134 cites W2060930865 @default.
• W2996164134 cites W2071010503 @default.
• W2996164134 cites W2072411272 @default.
• W2996164134 cites W2078719918 @default.
• W2996164134 cites W2088022688 @default.
• W2996164134 cites W2089254126 @default.
• W2996164134 cites W2093818708 @default.
• W2996164134 cites W2107908886 @default.
• W2996164134 cites W2116104054 @default.
• W2996164134 cites W2151013106 @default.
• W2996164134 cites W2157155777 @default.
• W2996164134 cites W2192533162 @default.
• W2996164134 cites W2301355574 @default.
• W2996164134 cites W2306104084 @default.
• W2996164134 cites W2509630779 @default.
• W2996164134 cites W2514666278 @default.
• W2996164134 cites W2516430890 @default.
• W2996164134 cites W2588683822 @default.
• W2996164134 cites W2589859055 @default.
• W2996164134 cites W2592585942 @default.
• W2996164134 cites W2602848567 @default.
• W2996164134 cites W2624346565 @default.
• W2996164134 cites W2625712295 @default.
• W2996164134 cites W2747254185 @default.
• W2996164134 cites W2770857514 @default.
• W2996164134 cites W2784395700 @default.
• W2996164134 cites W2788263670 @default.
• W2996164134 cites W2800863989 @default.
• W2996164134 cites W2801477130 @default.
• W2996164134 cites W2808795969 @default.
• W2996164134 cites W2809282001 @default.
• W2996164134 cites W2897559733 @default.
• W2996164134 cites W2923300855 @default.
• W2996164134 cites W2936664461 @default.
• W2996164134 cites W2946721812 @default.
• W2996164134 cites W2949575059 @default.
• W2996164134 cites W2952650776 @default.
• W2996164134 cites W2956029799 @default.
• W2996164134 cites W2959362600 @default.
• W2996164134 doi "https://doi.org/10.1097/cco.0000000000000602" @default.
• W2996164134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31833957" @default.
• W2996164134 hasPublicationYear "2020" @default.
• W2996164134 type Work @default.
• W2996164134 sameAs 2996164134 @default.
• W2996164134 citedByCount "17" @default.
• W2996164134 countsByYear W29961641342020 @default.
• W2996164134 countsByYear W29961641342021 @default.
• W2996164134 countsByYear W29961641342022 @default.
• W2996164134 crossrefType "journal-article" @default.
• W2996164134 hasAuthorship W2996164134A5028715904 @default.
• W2996164134 hasAuthorship W2996164134A5033044950 @default.
• W2996164134 hasAuthorship W2996164134A5066859773 @default.
• W2996164134 hasConcept C104317684 @default.
• W2996164134 hasConcept C142724271 @default.
• W2996164134 hasConcept C150194340 @default.
• W2996164134 hasConcept C162317418 @default.
• W2996164134 hasConcept C2776107976 @default.
• W2996164134 hasConcept C2780007613 @default.
• W2996164134 hasConcept C3020616263 @default.
• W2996164134 hasConcept C502942594 @default.
• W2996164134 hasConcept C54355233 @default.
• W2996164134 hasConcept C70721500 @default.
• W2996164134 hasConcept C71924100 @default.
• W2996164134 hasConcept C86803240 @default.
• W2996164134 hasConceptScore W2996164134C104317684 @default.
• W2996164134 hasConceptScore W2996164134C142724271 @default.
• W2996164134 hasConceptScore W2996164134C150194340 @default.
• W2996164134 hasConceptScore W2996164134C162317418 @default.
• W2996164134 hasConceptScore W2996164134C2776107976 @default.
• W2996164134 hasConceptScore W2996164134C2780007613 @default.
• W2996164134 hasConceptScore W2996164134C3020616263 @default.
• W2996164134 hasConceptScore W2996164134C502942594 @default.
• W2996164134 hasConceptScore W2996164134C54355233 @default.
• W2996164134 hasConceptScore W2996164134C70721500 @default.
• W2996164134 hasConceptScore W2996164134C71924100 @default.
• W2996164134 hasConceptScore W2996164134C86803240 @default.

• next