Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996258082> ?p ?o ?g. }
- W2996258082 endingPage "119396" @default.
- W2996258082 startingPage "119396" @default.
- W2996258082 abstract "Abstract We report the synthesis and characterization of novel pentamethylcyclopentadienyl (Cp*) iridium(III) complexes [(Cp*)Ir(4-methyl-4′-carboxy-2,2′-bipyridine)Cl]PF6 (Ir-I), the product (Ir-II) from amide coupling of Ir-I to dibenzocyclooctyne-amine, and its conjugate (Ir-CP) with the cyclic nona-peptide c(CRWYDENAC). The familiar three-legged ‘piano-stool’ configuration for complex Ir-I was confirmed by its single crystal X-ray structure. Significantly, copper-free click strategy has been developed for site-specific conjugation of the parent complex Ir-I to the tumour targeting nona-cyclic peptide. The approach consisted of two steps: (i) the carboxylic acid group of the bipyridine ligand in complex Ir-I was first attached to an amine functionalized dibenzocyclooctyne group via amide formation to generate complex Ir-II; and (ii) the alkyne bond of dibenzocyclooctyne in complex Ir-II underwent a subsequent strain-promoted copper-free cycloaddition with the azide group of the modified peptide. Interestingly, while complex Ir-I was inactive towards A2780 human ovarian cancer cells, complex Ir-II exhibited moderate cytotoxic activity. Targeted complexes such as Ir-CP offer scope for enhanced activity and selectivity of this class of anticancer complexes." @default.
- W2996258082 created "2019-12-26" @default.
- W2996258082 creator A5010278693 @default.
- W2996258082 creator A5039909130 @default.
- W2996258082 creator A5041800171 @default.
- W2996258082 creator A5045714214 @default.
- W2996258082 creator A5046225712 @default.
- W2996258082 creator A5051966189 @default.
- W2996258082 creator A5052501867 @default.
- W2996258082 creator A5057196333 @default.
- W2996258082 creator A5059210544 @default.
- W2996258082 creator A5071855899 @default.
- W2996258082 creator A5072945901 @default.
- W2996258082 date "2020-04-01" @default.
- W2996258082 modified "2023-10-11" @default.
- W2996258082 title "Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry" @default.
- W2996258082 cites W1752177536 @default.
- W2996258082 cites W1963912133 @default.
- W2996258082 cites W1968556710 @default.
- W2996258082 cites W1973676568 @default.
- W2996258082 cites W1987334051 @default.
- W2996258082 cites W1989368359 @default.
- W2996258082 cites W1991173346 @default.
- W2996258082 cites W1998929273 @default.
- W2996258082 cites W2017356685 @default.
- W2996258082 cites W2019563742 @default.
- W2996258082 cites W2021699049 @default.
- W2996258082 cites W2026875674 @default.
- W2996258082 cites W2027542963 @default.
- W2996258082 cites W2033499737 @default.
- W2996258082 cites W2059205366 @default.
- W2996258082 cites W2060436795 @default.
- W2996258082 cites W2060767646 @default.
- W2996258082 cites W2077605453 @default.
- W2996258082 cites W2086156429 @default.
- W2996258082 cites W2099402486 @default.
- W2996258082 cites W2108137054 @default.
- W2996258082 cites W2126183505 @default.
- W2996258082 cites W2130237005 @default.
- W2996258082 cites W2136809264 @default.
- W2996258082 cites W2138236417 @default.
- W2996258082 cites W2151709132 @default.
- W2996258082 cites W2157271026 @default.
- W2996258082 cites W2166402525 @default.
- W2996258082 cites W2171087569 @default.
- W2996258082 cites W2252977645 @default.
- W2996258082 cites W2282989227 @default.
- W2996258082 cites W2335547958 @default.
- W2996258082 cites W2583257650 @default.
- W2996258082 cites W2599530891 @default.
- W2996258082 cites W2618367377 @default.
- W2996258082 cites W2766433125 @default.
- W2996258082 cites W2769617661 @default.
- W2996258082 cites W2787263985 @default.
- W2996258082 cites W2787349695 @default.
- W2996258082 cites W2889006785 @default.
- W2996258082 cites W2896130004 @default.
- W2996258082 cites W2909963991 @default.
- W2996258082 cites W2910333849 @default.
- W2996258082 cites W2913145227 @default.
- W2996258082 cites W2942452957 @default.
- W2996258082 cites W2947361463 @default.
- W2996258082 cites W2968087747 @default.
- W2996258082 cites W2971159930 @default.
- W2996258082 doi "https://doi.org/10.1016/j.ica.2019.119396" @default.
- W2996258082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7610455" @default.
- W2996258082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33776131" @default.
- W2996258082 hasPublicationYear "2020" @default.
- W2996258082 type Work @default.
- W2996258082 sameAs 2996258082 @default.
- W2996258082 citedByCount "11" @default.
- W2996258082 countsByYear W29962580822020 @default.
- W2996258082 countsByYear W29962580822021 @default.
- W2996258082 countsByYear W29962580822022 @default.
- W2996258082 countsByYear W29962580822023 @default.
- W2996258082 crossrefType "journal-article" @default.
- W2996258082 hasAuthorship W2996258082A5010278693 @default.
- W2996258082 hasAuthorship W2996258082A5039909130 @default.
- W2996258082 hasAuthorship W2996258082A5041800171 @default.
- W2996258082 hasAuthorship W2996258082A5045714214 @default.
- W2996258082 hasAuthorship W2996258082A5046225712 @default.
- W2996258082 hasAuthorship W2996258082A5051966189 @default.
- W2996258082 hasAuthorship W2996258082A5052501867 @default.
- W2996258082 hasAuthorship W2996258082A5057196333 @default.
- W2996258082 hasAuthorship W2996258082A5059210544 @default.
- W2996258082 hasAuthorship W2996258082A5071855899 @default.
- W2996258082 hasAuthorship W2996258082A5072945901 @default.
- W2996258082 hasBestOaLocation W29962580821 @default.
- W2996258082 hasConcept C161790260 @default.
- W2996258082 hasConcept C178790620 @default.
- W2996258082 hasConcept C185592680 @default.
- W2996258082 hasConcept C21951064 @default.
- W2996258082 hasConcept C528581852 @default.
- W2996258082 hasConcept C544778455 @default.
- W2996258082 hasConcept C55493867 @default.
- W2996258082 hasConcept C69610077 @default.
- W2996258082 hasConcept C71240020 @default.
- W2996258082 hasConceptScore W2996258082C161790260 @default.