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- W2996259211 endingPage "107132" @default.
- W2996259211 startingPage "107132" @default.
- W2996259211 abstract "Experience-dependent neuronal plasticity is a fundamental substrate of learning and memory. Intrinsic excitability is a form of neuronal plasticity that can be altered by learning and indicates the pattern of neuronal responding to external stimuli (e.g. a learning or synaptic event). Associative fear conditioning is one form of learning that alters intrinsic excitability, reflecting an experience-dependent change in neuronal function. After fear conditioning, intrinsic excitability changes are evident in brain regions that are a critical part of the fear circuit, including the amygdala, hippocampus, retrosplenial cortex, and prefrontal cortex. Some of these changes are transient and/or reversed by extinction as well as learning-specific (i.e. they are not observed in neurons from control animals). This review will explore how intrinsic neuronal excitability changes within brain structures that are critical for fear learning, and it will also discuss evidence promoting intrinsic excitability as a vital mechanism of associative fear memories. This work has raised interesting questions regarding the role of fear learning in changes of intrinsic excitability within specific subpopulations of neurons, including those that express immediate early genes and thus demonstrate experience-dependent activity, as well as in neurons classified as having a specific firing type (e.g. burst-spiking vs. regular-spiking). These findings have interesting implications for how intrinsic excitability can serve as a neural substrate of learning and memory, and suggest that intrinsic plasticity within specific subpopulations of neurons may promote consolidation of the memory trace in a flexible and efficient manner." @default.
- W2996259211 created "2019-12-26" @default.
- W2996259211 creator A5016733731 @default.
- W2996259211 creator A5047431138 @default.
- W2996259211 creator A5050980920 @default.
- W2996259211 creator A5072830191 @default.
- W2996259211 creator A5090600373 @default.
- W2996259211 date "2020-01-01" @default.
- W2996259211 modified "2023-10-11" @default.
- W2996259211 title "Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit" @default.
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