Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996262022> ?p ?o ?g. }
- W2996262022 abstract "Abstract The mouse ( Mus musculus ) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g. CDKN1A, MDM2, BBC3 , and CCNG1 ) or down-regulated (e.g. TCF4 and MYC ) in both species after irradiation at ~4 and 8 Gy. However, we have also found genes that are consistently up-regulated in humans and down-regulated in mice (e.g. DDB2, PCNA, GADD45A, SESN1, RRM2B, KCNN4, IFI30 , and PTPRO ). Here we test a hematopoietically humanized mouse as a potential in vivo model for biodosimetry studies, measuring the response of these 14 genes one day after irradiation at 2 and 4 Gy, and comparing it with that of human blood irradiated ex vivo , and blood from whole body irradiated mice. We found that human blood cells in the hematopoietically humanized mouse in vivo environment recapitulated the gene expression pattern expected from human cells, not the pattern seen from in vivo irradiated normal mice. The results of this study support the use of hematopoietically humanized mice as an in vivo model for screening of radiation response genes relevant to humans." @default.
- W2996262022 created "2019-12-26" @default.
- W2996262022 creator A5008919275 @default.
- W2996262022 creator A5015571650 @default.
- W2996262022 creator A5039752024 @default.
- W2996262022 creator A5044358814 @default.
- W2996262022 creator A5065919062 @default.
- W2996262022 date "2019-12-19" @default.
- W2996262022 modified "2023-10-12" @default.
- W2996262022 title "Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers" @default.
- W2996262022 cites W108551223 @default.
- W2996262022 cites W1964861356 @default.
- W2996262022 cites W1966791160 @default.
- W2996262022 cites W1966897977 @default.
- W2996262022 cites W1971704900 @default.
- W2996262022 cites W1977135648 @default.
- W2996262022 cites W1979856058 @default.
- W2996262022 cites W1982801911 @default.
- W2996262022 cites W1991909246 @default.
- W2996262022 cites W1999420100 @default.
- W2996262022 cites W2001722118 @default.
- W2996262022 cites W2002835770 @default.
- W2996262022 cites W2005272949 @default.
- W2996262022 cites W2013553061 @default.
- W2996262022 cites W2014968377 @default.
- W2996262022 cites W2024123171 @default.
- W2996262022 cites W2025835234 @default.
- W2996262022 cites W2028207904 @default.
- W2996262022 cites W2029884468 @default.
- W2996262022 cites W2030532945 @default.
- W2996262022 cites W2033548186 @default.
- W2996262022 cites W2035066592 @default.
- W2996262022 cites W2035462635 @default.
- W2996262022 cites W2035625246 @default.
- W2996262022 cites W2042088532 @default.
- W2996262022 cites W2044354693 @default.
- W2996262022 cites W2049881915 @default.
- W2996262022 cites W2050428229 @default.
- W2996262022 cites W2060420406 @default.
- W2996262022 cites W2065103652 @default.
- W2996262022 cites W2066378731 @default.
- W2996262022 cites W2070317104 @default.
- W2996262022 cites W2073137689 @default.
- W2996262022 cites W2078031944 @default.
- W2996262022 cites W2085871516 @default.
- W2996262022 cites W2088515466 @default.
- W2996262022 cites W2091879550 @default.
- W2996262022 cites W2092835558 @default.
- W2996262022 cites W2094170505 @default.
- W2996262022 cites W2101839601 @default.
- W2996262022 cites W2104287165 @default.
- W2996262022 cites W2107739085 @default.
- W2996262022 cites W2109963121 @default.
- W2996262022 cites W2114570899 @default.
- W2996262022 cites W2124142827 @default.
- W2996262022 cites W2125471952 @default.
- W2996262022 cites W2128926100 @default.
- W2996262022 cites W2131104676 @default.
- W2996262022 cites W2132345612 @default.
- W2996262022 cites W2137906256 @default.
- W2996262022 cites W2139255177 @default.
- W2996262022 cites W2141326128 @default.
- W2996262022 cites W2145254159 @default.
- W2996262022 cites W2151103319 @default.
- W2996262022 cites W2153586002 @default.
- W2996262022 cites W2161771297 @default.
- W2996262022 cites W2164070247 @default.
- W2996262022 cites W2166274230 @default.
- W2996262022 cites W2255244472 @default.
- W2996262022 cites W2255334215 @default.
- W2996262022 cites W2564333599 @default.
- W2996262022 cites W2584624369 @default.
- W2996262022 cites W2593935119 @default.
- W2996262022 cites W2598546779 @default.
- W2996262022 cites W2624988670 @default.
- W2996262022 cites W2766608991 @default.
- W2996262022 cites W2774396895 @default.
- W2996262022 cites W2785064857 @default.
- W2996262022 cites W3043125680 @default.
- W2996262022 cites W3149695318 @default.
- W2996262022 cites W753103395 @default.
- W2996262022 cites W848974081 @default.
- W2996262022 doi "https://doi.org/10.1038/s41598-019-55982-2" @default.
- W2996262022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6923394" @default.
- W2996262022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31857640" @default.
- W2996262022 hasPublicationYear "2019" @default.
- W2996262022 type Work @default.
- W2996262022 sameAs 2996262022 @default.
- W2996262022 citedByCount "22" @default.
- W2996262022 countsByYear W29962620222020 @default.
- W2996262022 countsByYear W29962620222021 @default.
- W2996262022 countsByYear W29962620222022 @default.
- W2996262022 countsByYear W29962620222023 @default.
- W2996262022 crossrefType "journal-article" @default.
- W2996262022 hasAuthorship W2996262022A5008919275 @default.
- W2996262022 hasAuthorship W2996262022A5015571650 @default.
- W2996262022 hasAuthorship W2996262022A5039752024 @default.
- W2996262022 hasAuthorship W2996262022A5044358814 @default.
- W2996262022 hasAuthorship W2996262022A5065919062 @default.
- W2996262022 hasBestOaLocation W29962620221 @default.