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- W2996297997 abstract "The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes." @default.
- W2996297997 created "2019-12-26" @default.
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- W2996297997 date "2020-02-01" @default.
- W2996297997 modified "2023-10-04" @default.
- W2996297997 title "Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss" @default.
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- W2996297997 doi "https://doi.org/10.1016/j.cmet.2019.11.018" @default.
- W2996297997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31866441" @default.
- W2996297997 hasPublicationYear "2020" @default.
- W2996297997 type Work @default.