FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996346053> ?p ?o ?g. }

• W2996346053 endingPage "40" @default.
• W2996346053 startingPage "29" @default.
• W2996346053 abstract "Stimulation adjustment is required to optimise outcomes of deep brain stimulation (DBS) for treatment-resistant depression, but controlled data for ideal stimulation parameters are poor or insufficient. We aimed to establish the efficacy and safety of short pulse width (SPW) and long pulse width (LPW) subcallosal cingulate DBS in depression.We did a double-blind, randomised, crossover trial in an academic hospital in Calgary, AB, Canada. Patients had DSM IV-defined major depressive disorder and bipolar depression (20-70 years old, both sexes) and did not respond to treatment for more than 1 year, with a score of 20 or more on the 17-item Hamilton Depression Rating Scale (HDRS) at recruitment. Patients underwent bilateral DBS implantation into the subcallosal cingulate white matter using diffusion tensor imaging tractography. Patients were randomly assigned 1:1 without stratification using a computerised list generator to receive either SPW (90 μs) or LPW (210-450 μs) stimulation for 6 months. Patients and the clinician assessing outcomes were masked to the stimulation group. Keeping frequency constant (130 Hz), either pulse width or voltage was increased monthly, based on response using the HDRS. Patients who did not respond to treatment (<50% reduction in HDRS from baseline) at 6 months crossed over to the opposite stimulation for another 6 months. All patients received individualised cognitive behavioural therapy (CBT) for 12 weeks. The primary outcome was change in HDRS at 6 months and 12 months using intention-to-treat analysis. This study is registered with ClinicalTrials.gov, NCT01983904.Between Dec 5, 2013, and Sept 30, 2016, of 225 patients screened for eligibility, 23 patients were selected for DBS surgery. After one patient withdrew, 22 (mean age 46·4 years, SEM 3·1; 10 [45%] female, 12 [55%] male) were randomly assigned, ten (45%) to LPW stimulation and 12 (55%) to SPW stimulation. Patients were followed up at 6 months and 12 months. There was a significant reduction in HDRS scores (p<0·0001) with no difference between SPW and LPW groups (p=0·54) in the randomisation phase at 6 months. Crossover groups did not show a significant decrease in HDRS within groups (p=0·15) and between groups (p=0·21) from 6-12 months. Adverse events were equal between groups. Worsening anxiety and depression were the most common psychological adverse events. One patient in the SPW group died by suicide.Both LPW and SPW stimulation of subcallosal cingulate white matter tracts carried similar risks and were equally effective in reducing depressive symptoms, suggesting a role for both pulse width and amplitude titration in optimising clinical outcomes in patients with treatment-resistant depression.Alberta Innovates Health Solutions." @default.
• W2996346053 created "2019-12-26" @default.
• W2996346053 creator A5005367845 @default.
• W2996346053 creator A5018864007 @default.
• W2996346053 creator A5026830121 @default.
• W2996346053 creator A5034591519 @default.
• W2996346053 creator A5036404464 @default.
• W2996346053 creator A5056904269 @default.
• W2996346053 creator A5063029101 @default.
• W2996346053 date "2020-01-01" @default.
• W2996346053 modified "2023-10-16" @default.
• W2996346053 title "Long versus short pulse width subcallosal cingulate stimulation for treatment-resistant depression: a randomised, double-blind, crossover trial" @default.
• W2996346053 cites W1600943356 @default.
• W2996346053 cites W1869776851 @default.
• W2996346053 cites W1952951183 @default.
• W2996346053 cites W1964261330 @default.
• W2996346053 cites W2021744708 @default.
• W2996346053 cites W2023619652 @default.
• W2996346053 cites W2023721345 @default.
• W2996346053 cites W2047535883 @default.
• W2996346053 cites W2051101627 @default.
• W2996346053 cites W2062865989 @default.
• W2996346053 cites W2072296702 @default.
• W2996346053 cites W2105399857 @default.
• W2996346053 cites W2114613490 @default.
• W2996346053 cites W2128667519 @default.
• W2996346053 cites W2128682567 @default.
• W2996346053 cites W2131823335 @default.
• W2996346053 cites W2132098276 @default.
• W2996346053 cites W2132969335 @default.
• W2996346053 cites W2151821422 @default.
• W2996346053 cites W2157157023 @default.
• W2996346053 cites W2160070901 @default.
• W2996346053 cites W2315767303 @default.
• W2996346053 cites W2575380343 @default.
• W2996346053 cites W2606960287 @default.
• W2996346053 cites W2761803381 @default.
• W2996346053 cites W2763173694 @default.
• W2996346053 cites W2777987555 @default.
• W2996346053 cites W2784658672 @default.
• W2996346053 cites W2801402717 @default.
• W2996346053 cites W2809637028 @default.
• W2996346053 doi "https://doi.org/10.1016/s2215-0366(19)30415-8" @default.
• W2996346053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31860455" @default.
• W2996346053 hasPublicationYear "2020" @default.
• W2996346053 type Work @default.
• W2996346053 sameAs 2996346053 @default.
• W2996346053 citedByCount "46" @default.
• W2996346053 countsByYear W29963460532020 @default.
• W2996346053 countsByYear W29963460532021 @default.
• W2996346053 countsByYear W29963460532022 @default.
• W2996346053 countsByYear W29963460532023 @default.
• W2996346053 crossrefType "journal-article" @default.
• W2996346053 hasAuthorship W2996346053A5005367845 @default.
• W2996346053 hasAuthorship W2996346053A5018864007 @default.
• W2996346053 hasAuthorship W2996346053A5026830121 @default.
• W2996346053 hasAuthorship W2996346053A5034591519 @default.
• W2996346053 hasAuthorship W2996346053A5036404464 @default.
• W2996346053 hasAuthorship W2996346053A5056904269 @default.
• W2996346053 hasAuthorship W2996346053A5063029101 @default.
• W2996346053 hasConcept C118552586 @default.
• W2996346053 hasConcept C126322002 @default.
• W2996346053 hasConcept C138496976 @default.
• W2996346053 hasConcept C139719470 @default.
• W2996346053 hasConcept C142724271 @default.
• W2996346053 hasConcept C15744967 @default.
• W2996346053 hasConcept C162324750 @default.
• W2996346053 hasConcept C168563851 @default.
• W2996346053 hasConcept C1862650 @default.
• W2996346053 hasConcept C204787440 @default.
• W2996346053 hasConcept C24998067 @default.
• W2996346053 hasConcept C27081682 @default.
• W2996346053 hasConcept C2776867660 @default.
• W2996346053 hasConcept C2778542668 @default.
• W2996346053 hasConcept C2779134260 @default.
• W2996346053 hasConcept C2779734285 @default.
• W2996346053 hasConcept C2780051608 @default.
• W2996346053 hasConcept C2780733359 @default.
• W2996346053 hasConcept C71924100 @default.
• W2996346053 hasConcept C83849319 @default.
• W2996346053 hasConcept C87813604 @default.
• W2996346053 hasConcept C99508421 @default.
• W2996346053 hasConceptScore W2996346053C118552586 @default.
• W2996346053 hasConceptScore W2996346053C126322002 @default.
• W2996346053 hasConceptScore W2996346053C138496976 @default.
• W2996346053 hasConceptScore W2996346053C139719470 @default.
• W2996346053 hasConceptScore W2996346053C142724271 @default.
• W2996346053 hasConceptScore W2996346053C15744967 @default.
• W2996346053 hasConceptScore W2996346053C162324750 @default.
• W2996346053 hasConceptScore W2996346053C168563851 @default.
• W2996346053 hasConceptScore W2996346053C1862650 @default.
• W2996346053 hasConceptScore W2996346053C204787440 @default.
• W2996346053 hasConceptScore W2996346053C24998067 @default.
• W2996346053 hasConceptScore W2996346053C27081682 @default.
• W2996346053 hasConceptScore W2996346053C2776867660 @default.
• W2996346053 hasConceptScore W2996346053C2778542668 @default.
• W2996346053 hasConceptScore W2996346053C2779134260 @default.
• W2996346053 hasConceptScore W2996346053C2779734285 @default.

• next