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- W2996362238 abstract "Significance Circadian clocks are present in most cells of the body and act in concert to coordinate our daily physiology and behavior with the environment. Circadian misalignment between body clocks and the environment has been implicated in various pathologies. Here, we show that circadian misalignment can also occur between clocks of different peripheral tissues following exposure to hypoxia and that it stems from the differential response of core clock components to hypoxia. Intertissue circadian misalignment also occurs upon intermittent hypoxia, a model for obstructive sleep apnea (OSA). Our findings highlight the potential role of internal circadian misalignment in the pathophysiology of OSA and potentially other hypoxia-related diseases." @default.
- W2996362238 created "2019-12-26" @default.
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- W2996362238 date "2019-12-17" @default.
- W2996362238 modified "2023-09-27" @default.
- W2996362238 title "Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment" @default.
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- W2996362238 doi "https://doi.org/10.1073/pnas.1914112117" @default.
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