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- W2996366296 abstract "The present investigation is aimed at evaluating antimicrobial, antioxidant and anticancer properties of leaf extracts of Capparis brevispina DC (CB). The plant CB has many medicinal properties and is used as a traditional medicine in India, but to date, no scientific validation has been reported. The plant (CB) leaves were dried under shade and extracted using four different solvents sequentially, in the ascending order of polarity by using Soxhlet apparatus. These extracts were subjected to phytochemical analysis, antimicrobial (well diffusion), antioxidant (DPPH, ABTS, and phosphomolybdenum method) and anticancer (MTT assay) studies. In the antimicrobial study, different extracts of CB showed minimum inhibition against Gram-negative bacteria and selected fungi, but resistance against Gram-positive bacteria. Of the various extracts, ethanol and water extracts showed good antioxidant activity using all the three methods. The flavonoid and phenolic content of water extracts were higher when compared to all other extracts, hence the aqueous extracts was analyzed for its anticancer activity against HeLa cell line by MTT assay. The results showed a reasonable anticancer nature of the water extract of CB leaves (IC50 = 52.0 μg/mL). The phytochemicals or their combination which is present in aqueous extract of CB may be responsible for the antioxidant and cytotoxic activity of the plant." @default.
- W2996366296 created "2019-12-26" @default.
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- W2996366296 date "2020-01-01" @default.
- W2996366296 modified "2023-09-25" @default.
- W2996366296 title "Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae)) leaf extracts" @default.
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- W2996366296 doi "https://doi.org/10.1016/j.eujim.2019.101038" @default.
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