Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996379969> ?p ?o ?g. }
- W2996379969 abstract "Background: Efficacy of an intervention is commonly evaluated using P values, in addition to effect size measures such as absolute risk reduction, relative risk reduction, and numbers needed to treat. However, these measures are not always intuitive to clinicians. The fragility index (FI) is a more intuitive number that can facilitate interpretation but can only be used with binary outcomes. FI is the minimum number of patients who must be moved from the nonevent group to the event group to turn a significant result nonsignificant. In this retrospective analysis, we assessed the robustness of cardiovascular randomized controlled trials (RCTs), which report a positive (statistically significant) primary outcome by using the FI. Methods and Results: We searched Medline from 2007 to 2017 to identify cardiovascular RCTs published in 6 high impact journals ( The Lancet , New England Journal of Medicine , Journal of the American Medical Association , Circulation , Journal of the American College of Cardiology and European Heart Journal ). Only RCTs with sample sizes >500 and a 2-by-2 factorial design or dichotomous primary outcomes were selected. FI was calculated using a defined approach. Among the cohort of 123 RCTs that met inclusion criteria, median FI was 13 (interquartile range, 5–26). In 28 trials (22.8%), FI ranged between 1 and 4. In 37 trials (30.1%), number of patients lost to follow-up was higher than the FI. Pharmaceutical interventions had higher FI compared with other interventions, FI=19 (7–52; P =0.002). Median FI varied according to subspecialty (electrophysiology=2; heart failure=11; interventional cardiology=8; P =0.020) and multiregional RCTs had higher FI=22 (12–53.25; P =0.023). FI did not differ based on risk of bias indicators, funding, or publication year. Conclusions: Considerable variations in FI were observed among cardiovascular trials, suggesting the need for careful interpretation of results, particularly when number of patients lost to follow-up exceeds FI." @default.
- W2996379969 created "2019-12-26" @default.
- W2996379969 creator A5001427605 @default.
- W2996379969 creator A5008189923 @default.
- W2996379969 creator A5024602481 @default.
- W2996379969 creator A5027233990 @default.
- W2996379969 creator A5049702888 @default.
- W2996379969 creator A5051181579 @default.
- W2996379969 creator A5054802858 @default.
- W2996379969 creator A5076951114 @default.
- W2996379969 creator A5084382690 @default.
- W2996379969 creator A5087174973 @default.
- W2996379969 date "2019-12-01" @default.
- W2996379969 modified "2023-10-13" @default.
- W2996379969 title "Fragility Index in Cardiovascular Randomized Controlled Trials" @default.
- W2996379969 cites W1828994992 @default.
- W2996379969 cites W1973748105 @default.
- W2996379969 cites W1977319231 @default.
- W2996379969 cites W2072380646 @default.
- W2996379969 cites W2158621858 @default.
- W2996379969 cites W2162508946 @default.
- W2996379969 cites W2164957370 @default.
- W2996379969 cites W2293040502 @default.
- W2996379969 cites W2295697473 @default.
- W2996379969 cites W2522573436 @default.
- W2996379969 cites W2557904139 @default.
- W2996379969 cites W2721592717 @default.
- W2996379969 cites W2748735210 @default.
- W2996379969 cites W2755497194 @default.
- W2996379969 cites W2755964661 @default.
- W2996379969 cites W2781523386 @default.
- W2996379969 cites W2784792012 @default.
- W2996379969 cites W2789241280 @default.
- W2996379969 cites W2790069858 @default.
- W2996379969 cites W2792091789 @default.
- W2996379969 cites W2808922673 @default.
- W2996379969 cites W2888151307 @default.
- W2996379969 cites W2901824386 @default.
- W2996379969 cites W2903974403 @default.
- W2996379969 cites W2914054974 @default.
- W2996379969 cites W2942675627 @default.
- W2996379969 cites W2956873218 @default.
- W2996379969 cites W4254178313 @default.
- W2996379969 doi "https://doi.org/10.1161/circoutcomes.119.005755" @default.
- W2996379969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7962007" @default.
- W2996379969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31822121" @default.
- W2996379969 hasPublicationYear "2019" @default.
- W2996379969 type Work @default.
- W2996379969 sameAs 2996379969 @default.
- W2996379969 citedByCount "30" @default.
- W2996379969 countsByYear W29963799692019 @default.
- W2996379969 countsByYear W29963799692020 @default.
- W2996379969 countsByYear W29963799692021 @default.
- W2996379969 countsByYear W29963799692022 @default.
- W2996379969 countsByYear W29963799692023 @default.
- W2996379969 crossrefType "journal-article" @default.
- W2996379969 hasAuthorship W2996379969A5001427605 @default.
- W2996379969 hasAuthorship W2996379969A5008189923 @default.
- W2996379969 hasAuthorship W2996379969A5024602481 @default.
- W2996379969 hasAuthorship W2996379969A5027233990 @default.
- W2996379969 hasAuthorship W2996379969A5049702888 @default.
- W2996379969 hasAuthorship W2996379969A5051181579 @default.
- W2996379969 hasAuthorship W2996379969A5054802858 @default.
- W2996379969 hasAuthorship W2996379969A5076951114 @default.
- W2996379969 hasAuthorship W2996379969A5084382690 @default.
- W2996379969 hasAuthorship W2996379969A5087174973 @default.
- W2996379969 hasBestOaLocation W29963799691 @default.
- W2996379969 hasConcept C105795698 @default.
- W2996379969 hasConcept C118552586 @default.
- W2996379969 hasConcept C119060515 @default.
- W2996379969 hasConcept C126322002 @default.
- W2996379969 hasConcept C129848803 @default.
- W2996379969 hasConcept C168563851 @default.
- W2996379969 hasConcept C17744445 @default.
- W2996379969 hasConcept C199539241 @default.
- W2996379969 hasConcept C27415008 @default.
- W2996379969 hasConcept C2779473830 @default.
- W2996379969 hasConcept C2780642338 @default.
- W2996379969 hasConcept C33923547 @default.
- W2996379969 hasConcept C44249647 @default.
- W2996379969 hasConcept C512399662 @default.
- W2996379969 hasConcept C71924100 @default.
- W2996379969 hasConcept C82789193 @default.
- W2996379969 hasConceptScore W2996379969C105795698 @default.
- W2996379969 hasConceptScore W2996379969C118552586 @default.
- W2996379969 hasConceptScore W2996379969C119060515 @default.
- W2996379969 hasConceptScore W2996379969C126322002 @default.
- W2996379969 hasConceptScore W2996379969C129848803 @default.
- W2996379969 hasConceptScore W2996379969C168563851 @default.
- W2996379969 hasConceptScore W2996379969C17744445 @default.
- W2996379969 hasConceptScore W2996379969C199539241 @default.
- W2996379969 hasConceptScore W2996379969C27415008 @default.
- W2996379969 hasConceptScore W2996379969C2779473830 @default.
- W2996379969 hasConceptScore W2996379969C2780642338 @default.
- W2996379969 hasConceptScore W2996379969C33923547 @default.
- W2996379969 hasConceptScore W2996379969C44249647 @default.
- W2996379969 hasConceptScore W2996379969C512399662 @default.
- W2996379969 hasConceptScore W2996379969C71924100 @default.
- W2996379969 hasConceptScore W2996379969C82789193 @default.
- W2996379969 hasIssue "12" @default.