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- W2996410132 endingPage "115767" @default.
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- W2996410132 abstract "The detailed chemical structure and chain conformation of a novel fucoidan from the sea cucumber Stichopus chloronotus (Fuc-Sc) were investigated by HPLC, IR, NMR spectroscopy and multi-angle light scattering. It mainly consisted of l-fucose and sulfate esters at mole ratio of 1.0:1.3 and contained a →3)-α-l-fucose-2S-(1→ linear backbone. Besides, the chain conformation parameters αη (0.658 ± 0.001) and αh (0.612 ± 0.002) indicated that Fuc-Sc exhibited a random coil conformation in PBS. The worm-like cylinder model parameters ML (526 g/mol•nm) and q (6.9 nm) confirmed that Fuc-Sc adopted a flexible chain. Fuc-Sc possessed negative charges and good thermal stability. Moreover, Fuc-Sc showed significant inhibition of lipid peroxidation and obvious activation effects on RAW 264.7 cells by promoting their proliferation and the production of NO and TNF-α. The present study facilitated further understanding of the structure-activity relationship of Fuc-Sc and its application in food and pharmacy industries." @default.
- W2996410132 created "2019-12-26" @default.
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- W2996410132 date "2020-03-01" @default.
- W2996410132 modified "2023-10-16" @default.
- W2996410132 title "Structure characterization, antioxidant and immunoregulatory properties of a novel fucoidan from the sea cucumber Stichopus chloronotus" @default.
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- W2996410132 doi "https://doi.org/10.1016/j.carbpol.2019.115767" @default.
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