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- W2996413761 abstract "Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry. Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing severity of DR (adjusted mean 51.93 vs. 49.89 vs. 47.96, P -trend = 0.005). Superficial and deep foveal avascular zone area increased with increasing DR severity (adjusted mean: 235.0 µ m 2 vs. 303.4 µ m 2 vs. 400.9 µ m 2 , P -trend = 0.003 [superficial]; 333.1 µ m 2 vs. 513.3 µ m 2 vs. 530.2 µ m 2 , P -trend = 0.001 [deep]). Retinal sensitivity decreased with increasing DR severity (adjusted mean: 25.12 dB vs. 22.34 dB vs. 20.67 dB, P -trend = 0.003). Retinal sensitivity correlated positively with deep perifoveal vessel density (Pearson's ρ = 0.276, P = 0.020) and inversely with superficial foveal avascular zone area (Pearson's ρ = −0.333, P = 0.010). Conclusion: Alterations in retinal microvasculature can be observed with OCTA with increasing severity of DR. These changes are correlated with reduced retinal sensitivity. Optical coherence tomography angiography is useful to detect and quantify the microvasculature properties of eyes with diabetic macular ischemia." @default.
- W2996413761 created "2019-12-26" @default.
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- W2996413761 date "2019-12-13" @default.
- W2996413761 modified "2023-10-17" @default.
- W2996413761 title "DIABETIC MACULAR ISCHEMIA" @default.
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- W2996413761 doi "https://doi.org/10.1097/iae.0000000000002721" @default.
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