FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996413905> ?p ?o ?g. }

• W2996413905 abstract "Introduction: Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in cardiovascular risk during pulmonary rehabilitation (assessed using aortic stiffness) are heterogeneous, suggesting that there may be sub-groups of patients who do and do not benefit. In COPD, cardiovascular comorbidity is common in patients hospitalised with exacerbations of COPD and this may negatively affect exacerbation recovery. Aim: To investigate the characteristics of COPD patients who do and do not experience aortic stiffness reduction during pulmonary rehabilitation, examine how changes relate to physical activity and exercise capacity, and assess whether changes in aortic stiffness are maintained at six weeks following rehabilitation. To identify the possibility of subsequent CV risk reduction during hospitalisation (from admission towards discharge). Methods: Firstly, a systematic review was conducted to assess the existing literature on the influence of pulmonary rehabilitation on cardiovascular risk in COPD measured by aortic pulse wave velocity. Next, we conducted a repeatability study to assess and understand the aPWV values generated by Vicorder (Skidmore Medical, Bristol, UK) software in healthy subjects prior to using it on patients. To better understand our population, we conducted a pre-pulmonary rehabilitation study to identify the associations of baseline cardiovascular risk in COPD patients, measured using aPWV, and to compare the results between groups with and without a reported history of CVD. The listed projects enabled the formulation of the research question and main PhD hypothesis, tested using a prospective cohort trial. Participants were enrolled in a PR course consisting of sessions two hours long, twice each week for six weeks, with complete pre- and post-measures, including aPWV. Next, we conducted a follow-up study to identify if there were any alterations in aortic stiffness following the completion of pulmonary rehabilitation. Lastly, we conducted a pilot study to understand whether cardiovascular risk (measured by aortic stiffness) is reduced in hospitalised COPD patients during exacerbation recovery towards discharge. Results: Existing studies that measured aPWV prior to and post-PR were small and heterogeneous with different sample sizes and programme length. The elevated aortic stiffness in COPD was independent from CVD history. Whilst on average there was no influence of PR on aortic stiffness, we report that 56% of patients responded with a significant reduction in aortic stiffness (11.5 vs 10.4m/s, p=<0.001). The change in aortic stiffness during rehabilitation was associated with both increased physical the respondents, 92% of the responders who attended maintained this response six week later. Finally, the elevated aortic stiffness seen in COPD hospitalised due to exacerbation was reduced at discharge (10.3 vs 10.1m/s, p=0.04). Conclusion Elevated aortic stiffness in COPD is potentially modifiable in a subgroup of patients during pulmonary rehabilitation and is associated with increased physical activity; this reduction is maintained at least six weeks later. In contrast, patients who appeared to have an increase in their aortic stiffness during PR were more likely to have a delayed PR response. For those COPD patients hospitalised due to exacerbation, aortic stiffness is reduced toward discharge." @default.
• W2996413905 created "2019-12-26" @default.
• W2996413905 creator A5023496202 @default.
• W2996413905 date "2019-08-28" @default.
• W2996413905 modified "2023-09-23" @default.
• W2996413905 title "Pulmonary rehabilitation and cardiovascular risk in COPD" @default.
• W2996413905 cites W122349615 @default.
• W2996413905 cites W1503617748 @default.
• W2996413905 cites W1854161682 @default.
• W2996413905 cites W1859996587 @default.
• W2996413905 cites W1885313913 @default.
• W2996413905 cites W1969105764 @default.
• W2996413905 cites W1976712582 @default.
• W2996413905 cites W1980994260 @default.
• W2996413905 cites W1987138414 @default.
• W2996413905 cites W1987730138 @default.
• W2996413905 cites W1987782531 @default.
• W2996413905 cites W1990426738 @default.
• W2996413905 cites W1991409194 @default.
• W2996413905 cites W2002719503 @default.
• W2996413905 cites W2005334676 @default.
• W2996413905 cites W2007527209 @default.
• W2996413905 cites W2007903763 @default.
• W2996413905 cites W2009494901 @default.
• W2996413905 cites W2010967671 @default.
• W2996413905 cites W2011876371 @default.
• W2996413905 cites W2014231512 @default.
• W2996413905 cites W2015588423 @default.
• W2996413905 cites W2016880082 @default.
• W2996413905 cites W2029238181 @default.
• W2996413905 cites W2030921088 @default.
• W2996413905 cites W2033881551 @default.
• W2996413905 cites W2037621633 @default.
• W2996413905 cites W2038414269 @default.
• W2996413905 cites W2038781080 @default.
• W2996413905 cites W2043828746 @default.
• W2996413905 cites W2044051732 @default.
• W2996413905 cites W2044406058 @default.
• W2996413905 cites W2047619514 @default.
• W2996413905 cites W2049977108 @default.
• W2996413905 cites W2052776501 @default.
• W2996413905 cites W2063483363 @default.
• W2996413905 cites W2063998910 @default.
• W2996413905 cites W2067222353 @default.
• W2996413905 cites W2072620908 @default.
• W2996413905 cites W2073263541 @default.
• W2996413905 cites W2085473145 @default.
• W2996413905 cites W2086872426 @default.
• W2996413905 cites W2095789696 @default.
• W2996413905 cites W2096517093 @default.
• W2996413905 cites W2096656439 @default.
• W2996413905 cites W2100294894 @default.
• W2996413905 cites W2100658531 @default.
• W2996413905 cites W2101262934 @default.
• W2996413905 cites W2102015915 @default.
• W2996413905 cites W2102435137 @default.
• W2996413905 cites W2103418109 @default.
• W2996413905 cites W2104738482 @default.
• W2996413905 cites W2106651585 @default.
• W2996413905 cites W2107147197 @default.
• W2996413905 cites W2107829061 @default.
• W2996413905 cites W2108249447 @default.
• W2996413905 cites W2108424624 @default.
• W2996413905 cites W2108619961 @default.
• W2996413905 cites W2111608431 @default.
• W2996413905 cites W2111722183 @default.
• W2996413905 cites W2112162293 @default.
• W2996413905 cites W2112334970 @default.
• W2996413905 cites W2112943642 @default.
• W2996413905 cites W2116177661 @default.
• W2996413905 cites W2117837864 @default.
• W2996413905 cites W2118214839 @default.
• W2996413905 cites W2120157356 @default.
• W2996413905 cites W2124523627 @default.
• W2996413905 cites W2125065061 @default.
• W2996413905 cites W2125097212 @default.
• W2996413905 cites W21256015 @default.
• W2996413905 cites W2126082863 @default.
• W2996413905 cites W2126553084 @default.
• W2996413905 cites W2133416234 @default.
• W2996413905 cites W2135112559 @default.
• W2996413905 cites W2135419134 @default.
• W2996413905 cites W2141403362 @default.
• W2996413905 cites W2142148686 @default.
• W2996413905 cites W2142856621 @default.
• W2996413905 cites W2143615989 @default.
• W2996413905 cites W2143691602 @default.
• W2996413905 cites W2143765657 @default.
• W2996413905 cites W2147483495 @default.
• W2996413905 cites W2148026472 @default.
• W2996413905 cites W2148966889 @default.
• W2996413905 cites W2150223912 @default.
• W2996413905 cites W2150277491 @default.
• W2996413905 cites W2151100203 @default.
• W2996413905 cites W2152569940 @default.
• W2996413905 cites W2156248782 @default.
• W2996413905 cites W2161586251 @default.
• W2996413905 cites W2164777277 @default.
• W2996413905 cites W2166432084 @default.
• W2996413905 cites W2167374836 @default.

• next