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• W2996426629 endingPage "104677" @default.
• W2996426629 startingPage "104677" @default.
• W2996426629 abstract "Wedelolactone (WDL) is a coumestan present in the plants Eclipta prostrata and Wedelia calendulacea which are used for treatment of a multitude of health problems in traditional medicine. It has previously been shown that WDL exerts antiviral activity against human immunodeficiency virus and hepatitis C virus. In this study, we investigated the effect of WDL on lytic human cytomegalovirus (HCMV) infection. We demonstrate a strong interference with HCMV replication as analyzed in multi-round replication settings. A more detailed analysis of the underlying mechanisms revealed that WDL acts at two distinct steps of the viral replication cycle. During immediate early (IE) times, we observe an inhibition of IE1/IE2 expression. Although WDL was reported to interfere with NF-κB signaling our results suggest the existence of additional mechanisms that impede viral IE expression. During later time points of infection, WDL induced a disruption of the interaction between EZH2 and EED, components of the virus-supportive polycomb repressive complex 2 (PRC2). Thereby, the stability of the PRC2 complex as well as the related complex PRC1 was disturbed leading to diminished viral DNA synthesis. Taken together, we identify WDL as a potent agent against HCMV which interferes at two distinct steps of viral replication." @default.
• W2996426629 created "2019-12-26" @default.
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• W2996426629 date "2020-02-01" @default.
• W2996426629 modified "2023-10-14" @default.
• W2996426629 title "Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle" @default.
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• W2996426629 doi "https://doi.org/10.1016/j.antiviral.2019.104677" @default.
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