FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996501216> ?p ?o ?g. }

• W2996501216 abstract "Reprogramming of metabolic pathways allows cancer cells to survive and thrive in the tumor microenvironment. Glycolysis-inducing factors including oncogenic KRAS mutations, loss of function in TP53 and hypoxia are prevalent in PDAC. Cholesterol and its metabolites support tumor cell growth and the mevalonate pathway, which uses glycolysis products for de novo cholesterol synthesis, has been found to be upregulated in cancer. However, whether intertumoral heterogeneity in these metabolic networks influences outcome in pancreatic cancer has not been well established. We profiled the expression of glycolytic and cholesterogenic genes in 325 resected and metastatic pancreatic ductal adenocarcinoma (PDAC) tumors and identified four distinct subgroups: quiescent, glycolytic, cholesterogenic, and mixed. Glycolytic tumors were associated with the shortest median survival in resectable and metastatic disease settings. Patients with cholesterogenic tumors had the longest median survival. KRAS and MYC amplified tumors had higher expression of glycolytic genes than tumors with normal or lost copies of these oncogenes. The mitochondrial uptake of pyruvate, the end product of glycolysis, facilitates the generation of acetyl-CoA for cholesterol synthesis. PDAC tumors with a glycolytic gene signature had the lowest expression of mitochondrial pyruvate carriers MPC1 and MPC2. Glycolytic and cholesterogenic gene expression correlated with the expression of reported prognostic PDAC subtype classifier genes. Our results indicate that PDAC tumors have unique metabolic profiles that influence disease outcome and provide functional correlate to previously identified subtypes. The findings also raise the possibility of a shift in balance between the glycolytic and cholesterogenic pathways as a factor in PDAC progression and a potential target for therapy. Citation Format: Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-li Wong, Michael K.C. Lee, Grainne M. O9Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer. Gene expression along the glycolysis-cholesterol synthesis axis and outcome in pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2019 Sept 6-9; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2019;79(24 Suppl):Abstract nr A24." @default.
• W2996501216 created "2019-12-26" @default.
• W2996501216 creator A5001731680 @default.
• W2996501216 creator A5003643368 @default.
• W2996501216 creator A5015015784 @default.
• W2996501216 creator A5017021482 @default.
• W2996501216 creator A5025091949 @default.
• W2996501216 creator A5031580027 @default.
• W2996501216 creator A5036473360 @default.
• W2996501216 creator A5038748484 @default.
• W2996501216 creator A5040463490 @default.
• W2996501216 creator A5048595020 @default.
• W2996501216 creator A5049385540 @default.
• W2996501216 creator A5054009874 @default.
• W2996501216 creator A5061402791 @default.
• W2996501216 creator A5065504460 @default.
• W2996501216 creator A5068644454 @default.
• W2996501216 creator A5070061359 @default.
• W2996501216 creator A5073611908 @default.
• W2996501216 creator A5081831776 @default.
• W2996501216 creator A5082292492 @default.
• W2996501216 creator A5085580353 @default.
• W2996501216 creator A5088325035 @default.
• W2996501216 creator A5091086534 @default.
• W2996501216 creator A5091747658 @default.
• W2996501216 date "2019-12-13" @default.
• W2996501216 modified "2023-10-11" @default.
• W2996501216 title "Abstract A24: Gene expression along the glycolysis-cholesterol synthesis axis and outcome in pancreatic cancer" @default.
• W2996501216 doi "https://doi.org/10.1158/1538-7445.panca19-a24" @default.
• W2996501216 hasPublicationYear "2019" @default.
• W2996501216 type Work @default.
• W2996501216 sameAs 2996501216 @default.
• W2996501216 citedByCount "0" @default.
• W2996501216 crossrefType "proceedings-article" @default.
• W2996501216 hasAuthorship W2996501216A5001731680 @default.
• W2996501216 hasAuthorship W2996501216A5003643368 @default.
• W2996501216 hasAuthorship W2996501216A5015015784 @default.
• W2996501216 hasAuthorship W2996501216A5017021482 @default.
• W2996501216 hasAuthorship W2996501216A5025091949 @default.
• W2996501216 hasAuthorship W2996501216A5031580027 @default.
• W2996501216 hasAuthorship W2996501216A5036473360 @default.
• W2996501216 hasAuthorship W2996501216A5038748484 @default.
• W2996501216 hasAuthorship W2996501216A5040463490 @default.
• W2996501216 hasAuthorship W2996501216A5048595020 @default.
• W2996501216 hasAuthorship W2996501216A5049385540 @default.
• W2996501216 hasAuthorship W2996501216A5054009874 @default.
• W2996501216 hasAuthorship W2996501216A5061402791 @default.
• W2996501216 hasAuthorship W2996501216A5065504460 @default.
• W2996501216 hasAuthorship W2996501216A5068644454 @default.
• W2996501216 hasAuthorship W2996501216A5070061359 @default.
• W2996501216 hasAuthorship W2996501216A5073611908 @default.
• W2996501216 hasAuthorship W2996501216A5081831776 @default.
• W2996501216 hasAuthorship W2996501216A5082292492 @default.
• W2996501216 hasAuthorship W2996501216A5085580353 @default.
• W2996501216 hasAuthorship W2996501216A5088325035 @default.
• W2996501216 hasAuthorship W2996501216A5091086534 @default.
• W2996501216 hasAuthorship W2996501216A5091747658 @default.
• W2996501216 hasConcept C121608353 @default.
• W2996501216 hasConcept C126322002 @default.
• W2996501216 hasConcept C134018914 @default.
• W2996501216 hasConcept C20251656 @default.
• W2996501216 hasConcept C2779256057 @default.
• W2996501216 hasConcept C2780210213 @default.
• W2996501216 hasConcept C2781187634 @default.
• W2996501216 hasConcept C502942594 @default.
• W2996501216 hasConcept C526805850 @default.
• W2996501216 hasConcept C54355233 @default.
• W2996501216 hasConcept C55885012 @default.
• W2996501216 hasConcept C62231903 @default.
• W2996501216 hasConcept C71924100 @default.
• W2996501216 hasConcept C86803240 @default.
• W2996501216 hasConceptScore W2996501216C121608353 @default.
• W2996501216 hasConceptScore W2996501216C126322002 @default.
• W2996501216 hasConceptScore W2996501216C134018914 @default.
• W2996501216 hasConceptScore W2996501216C20251656 @default.
• W2996501216 hasConceptScore W2996501216C2779256057 @default.
• W2996501216 hasConceptScore W2996501216C2780210213 @default.
• W2996501216 hasConceptScore W2996501216C2781187634 @default.
• W2996501216 hasConceptScore W2996501216C502942594 @default.
• W2996501216 hasConceptScore W2996501216C526805850 @default.
• W2996501216 hasConceptScore W2996501216C54355233 @default.
• W2996501216 hasConceptScore W2996501216C55885012 @default.
• W2996501216 hasConceptScore W2996501216C62231903 @default.
• W2996501216 hasConceptScore W2996501216C71924100 @default.
• W2996501216 hasConceptScore W2996501216C86803240 @default.
• W2996501216 hasLocation W29965012161 @default.
• W2996501216 hasOpenAccess W2996501216 @default.
• W2996501216 hasPrimaryLocation W29965012161 @default.
• W2996501216 hasRelatedWork W1274431 @default.
• W2996501216 hasRelatedWork W14548219 @default.
• W2996501216 hasRelatedWork W20407968 @default.
• W2996501216 hasRelatedWork W22633488 @default.
• W2996501216 hasRelatedWork W23185379 @default.
• W2996501216 hasRelatedWork W23296015 @default.
• W2996501216 hasRelatedWork W24722527 @default.
• W2996501216 hasRelatedWork W2644773 @default.
• W2996501216 hasRelatedWork W29497872 @default.
• W2996501216 hasRelatedWork W6834028 @default.
• W2996501216 isParatext "false" @default.
• W2996501216 isRetracted "false" @default.

• next