FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996535940> ?p ?o ?g. }

• W2996535940 endingPage "376" @default.
• W2996535940 startingPage "365" @default.
• W2996535940 abstract "Background: In 2016, the global number of individuals living with dementia was 43.8 million, representing a 117% increase from 1990—mainly due to increases in aging and population growth. Up to 90% of individuals with dementia experience neuropsychiatric symptoms (NPS). However, the limitations of current treatments for NPS have drivent he search for safer pharmacotherapies—including cannabinoids. Aim: To assess the efficacy and acceptability of cannabinoids for the treatment of NPS in individuals with dementia. Design: Systematic review and meta-analysis of clinical trials. Setting and participants: Of 6,902 papers, 9 were eligible ( n = 205, 44% female, 78 ± 7 years, 85% Alzheimer disease). Trials were in North America and Europe and explored tetrahydrocannabinol ( n = 3), dronabinol ( n = 5), or nabilone ( n = 1). Measurement: Titles/abstracts were independently screened by one reviewer and reviewed by a second. Full-text screening was by two reviewers with discrepancies resolved via a third reviewer. We extracted data on the standardized mean difference (SMD) for several NPS instruments, trial completion, and adverse events. Data were pooled using random-effects models. Findings: Cannabinoids led to significant improvements across NPS instruments, including the Cohen Mansfield Agitation Inventory (SMD = −0.80; 95% confidence interval [CI], −1.45 to −0.16), the Neuropsychiatric Inventory (SMD = −0.61; CI, −1.07 to −0.15), and nocturnal actigraphy (SMD = −1.05; CI, −1.56 to −0.54h). Cannabinoids were well-tolerated, with an overall trial completion rate of 93% (193/205) and no serious treatment-related adverse events. Treatment efficacy was associated with baseline dementia severity and dose, but not dementia subtype, age, or sex. The overall study quality was rated as low. Conclusions: There is preliminary evidence for the efficacy and tolerability of cannabinoids as treatments for NPS. Population-based studies are needed to characterize their real-world effectiveness and acceptability." @default.
• W2996535940 created "2019-12-26" @default.
• W2996535940 creator A5021568220 @default.
• W2996535940 creator A5022798675 @default.
• W2996535940 creator A5065329807 @default.
• W2996535940 date "2019-12-13" @default.
• W2996535940 modified "2023-10-17" @default.
• W2996535940 title "Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta-Analysis" @default.
• W2996535940 cites W1166074170 @default.
• W2996535940 cites W1190231942 @default.
• W2996535940 cites W1457264087 @default.
• W2996535940 cites W1774424727 @default.
• W2996535940 cites W1867600636 @default.
• W2996535940 cites W1964435302 @default.
• W2996535940 cites W1964734416 @default.
• W2996535940 cites W1965891153 @default.
• W2996535940 cites W1978062254 @default.
• W2996535940 cites W2005019545 @default.
• W2996535940 cites W2015987706 @default.
• W2996535940 cites W2020239320 @default.
• W2996535940 cites W2028794471 @default.
• W2996535940 cites W2029117346 @default.
• W2996535940 cites W2033585778 @default.
• W2996535940 cites W2034899947 @default.
• W2996535940 cites W2035133137 @default.
• W2996535940 cites W2037986006 @default.
• W2996535940 cites W2039589814 @default.
• W2996535940 cites W2044893214 @default.
• W2996535940 cites W2050994652 @default.
• W2996535940 cites W2055234065 @default.
• W2996535940 cites W2074249059 @default.
• W2996535940 cites W2088361570 @default.
• W2996535940 cites W2098025305 @default.
• W2996535940 cites W2099611723 @default.
• W2996535940 cites W2103247095 @default.
• W2996535940 cites W2109119080 @default.
• W2996535940 cites W2111689088 @default.
• W2996535940 cites W2112074033 @default.
• W2996535940 cites W2119898593 @default.
• W2996535940 cites W2120227293 @default.
• W2996535940 cites W2126930838 @default.
• W2996535940 cites W2132592055 @default.
• W2996535940 cites W2138883123 @default.
• W2996535940 cites W2139560403 @default.
• W2996535940 cites W2140616116 @default.
• W2996535940 cites W2143209864 @default.
• W2996535940 cites W2148054711 @default.
• W2996535940 cites W2148841660 @default.
• W2996535940 cites W2153775500 @default.
• W2996535940 cites W2157823046 @default.
• W2996535940 cites W2158197340 @default.
• W2996535940 cites W2169182197 @default.
• W2996535940 cites W2235609260 @default.
• W2996535940 cites W2293693569 @default.
• W2996535940 cites W2347042996 @default.
• W2996535940 cites W2395178533 @default.
• W2996535940 cites W2434649470 @default.
• W2996535940 cites W2468996569 @default.
• W2996535940 cites W2509699213 @default.
• W2996535940 cites W2514884437 @default.
• W2996535940 cites W2515660778 @default.
• W2996535940 cites W2516266560 @default.
• W2996535940 cites W2586415305 @default.
• W2996535940 cites W2608446001 @default.
• W2996535940 cites W2612555163 @default.
• W2996535940 cites W2720782040 @default.
• W2996535940 cites W2736307756 @default.
• W2996535940 cites W2754398248 @default.
• W2996535940 cites W2765769328 @default.
• W2996535940 cites W2766996755 @default.
• W2996535940 cites W2767138189 @default.
• W2996535940 cites W2778529108 @default.
• W2996535940 cites W2790877128 @default.
• W2996535940 cites W2883567930 @default.
• W2996535940 cites W2886018025 @default.
• W2996535940 cites W2903517662 @default.
• W2996535940 cites W2908155319 @default.
• W2996535940 cites W2914149777 @default.
• W2996535940 cites W2944032251 @default.
• W2996535940 cites W2946050384 @default.
• W2996535940 cites W96612992 @default.
• W2996535940 doi "https://doi.org/10.1177/0706743719892717" @default.
• W2996535940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7265608" @default.
• W2996535940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31835954" @default.
• W2996535940 hasPublicationYear "2019" @default.
• W2996535940 type Work @default.
• W2996535940 sameAs 2996535940 @default.
• W2996535940 citedByCount "25" @default.
• W2996535940 countsByYear W29965359402020 @default.
• W2996535940 countsByYear W29965359402021 @default.
• W2996535940 countsByYear W29965359402022 @default.
• W2996535940 countsByYear W29965359402023 @default.
• W2996535940 crossrefType "journal-article" @default.
• W2996535940 hasAuthorship W2996535940A5021568220 @default.
• W2996535940 hasAuthorship W2996535940A5022798675 @default.
• W2996535940 hasAuthorship W2996535940A5065329807 @default.
• W2996535940 hasBestOaLocation W29965359401 @default.
• W2996535940 hasConcept C118552586 @default.

• next