FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996548110> ?p ?o ?g. }

• W2996548110 endingPage "459" @default.
• W2996548110 startingPage "450" @default.
• W2996548110 abstract "Background: Large rotator cuff tears still represent a challenging problem in orthopaedics. The use of tenocytes on biomaterials/scaffolds for the repair of large rotator cuff defects might be a promising approach in the field of tendon regeneration. Hypothesis: Cultivated autologous tenocytes seeded on a collagen scaffold lead to enhanced histological and biomechanical results after rotator cuff repair in a sheep model as compared with unseeded scaffolds in an acute setting. Study Design: Controlled laboratory study. Methods: At the tendon-bone junction of the infraspinatus tendon of the right foreleg of 24 sheep, a 3.5 × 1.5–cm tendon defect was created. Sheep were randomly allocated to group 1, a defect; group 2, where an unseeded collagen scaffold was implanted; or group 3, which received the implantation of a collagen scaffold seeded with autologous tenocytes. Twelve weeks postoperatively, tendon regeneration was examined histologically and biomechanically. Results: The histology of the neotendons of group 3 showed better fiber patterns, a higher production of proteoglycans, and an increased genesis of collagen III in contrast to groups 1 and 2. Immunostaining revealed less tissue dedifferentiation, a more structured cartilage layer, and homogeneous cartilage-bone transition in group 3 in comparison with groups 1 and 2. Biomechanically, the tensile strength of the reconstructed tendons in group 3 (mean load to failure, 2516 N; SD, 407.5 N) was approximately 84% that of the native tendons (mean load to failure, 2995 N; SD, 223.1 N) without statistical significance. A significant difference ( P = .0095) was registered between group 1 (66.9% with a mean load to failure of 2004 N; SD, 273.8 N) and the native tendons, as well as between group 2 (69.7% with a mean load to failure of 2088 N; SD, 675.4 N) and the native tendons for mean ultimate tensile strength. In breaking stress, a significant difference ( P = .0095) was seen between group 1 (mean breaking stress, 1335 N/mm 2 ; SD, 182.7 N/mm 2 ) and the native tendons, as well as between group 2 (breaking stress, 1392 N/mm 2 ; SD, 450.2 N/mm 2 ) and the native tendons (mean breaking stress, 1996 N/mm 2 ; SD, 148.7 N/mm 2 ). Again, there was no significant difference between group 3 (mean breaking stress, 1677 N/mm 2 ; SD, 271.7 N/mm 2 ) and the native tendons. Conclusion: Autologous tenocytes seeded on collagen scaffolds yield enhanced biomechanical results after tendon-bone reconstruction as compared with unseeded scaffolds in an acute setting. Biomechanical results and histological outcomes were promising, showing that the use of autologous tenocytes with specific carrier matrices could be a novel approach for repairing rotator cuff tears. Clinical Relevance: This study supports the use of tenocytes and scaffolds for improving the quality of tendon-bone regeneration." @default.
• W2996548110 created "2019-12-26" @default.
• W2996548110 creator A5013567310 @default.
• W2996548110 creator A5015495373 @default.
• W2996548110 creator A5028833917 @default.
• W2996548110 creator A5032416661 @default.
• W2996548110 creator A5050095757 @default.
• W2996548110 creator A5057980545 @default.
• W2996548110 creator A5063267291 @default.
• W2996548110 creator A5069083414 @default.
• W2996548110 creator A5071270770 @default.
• W2996548110 creator A5080817499 @default.
• W2996548110 date "2019-12-16" @default.
• W2996548110 modified "2023-10-02" @default.
• W2996548110 title "Rotator Cuff Repair With Autologous Tenocytes and Biodegradable Collagen Scaffold: A Histological and Biomechanical Study in Sheep" @default.
• W2996548110 cites W1972788455 @default.
• W2996548110 cites W1977099928 @default.
• W2996548110 cites W1991696963 @default.
• W2996548110 cites W1993859063 @default.
• W2996548110 cites W1998650381 @default.
• W2996548110 cites W2002975382 @default.
• W2996548110 cites W2006835773 @default.
• W2996548110 cites W2015306400 @default.
• W2996548110 cites W2016592271 @default.
• W2996548110 cites W2018791669 @default.
• W2996548110 cites W2018882303 @default.
• W2996548110 cites W2039548378 @default.
• W2996548110 cites W2054338977 @default.
• W2996548110 cites W2059852515 @default.
• W2996548110 cites W2068362904 @default.
• W2996548110 cites W2076163108 @default.
• W2996548110 cites W2076648316 @default.
• W2996548110 cites W2078595898 @default.
• W2996548110 cites W2081595374 @default.
• W2996548110 cites W2085572225 @default.
• W2996548110 cites W2088863315 @default.
• W2996548110 cites W2104813287 @default.
• W2996548110 cites W2124138789 @default.
• W2996548110 cites W2133103125 @default.
• W2996548110 cites W2141168089 @default.
• W2996548110 cites W2146347942 @default.
• W2996548110 cites W2157780564 @default.
• W2996548110 cites W2158566091 @default.
• W2996548110 cites W2293054785 @default.
• W2996548110 cites W2475167489 @default.
• W2996548110 cites W4230239077 @default.
• W2996548110 cites W4255038051 @default.
• W2996548110 cites W4366658088 @default.
• W2996548110 doi "https://doi.org/10.1177/0363546519892580" @default.
• W2996548110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31841352" @default.
• W2996548110 hasPublicationYear "2019" @default.
• W2996548110 type Work @default.
• W2996548110 sameAs 2996548110 @default.
• W2996548110 citedByCount "26" @default.
• W2996548110 countsByYear W29965481102020 @default.
• W2996548110 countsByYear W29965481102021 @default.
• W2996548110 countsByYear W29965481102022 @default.
• W2996548110 countsByYear W29965481102023 @default.
• W2996548110 crossrefType "journal-article" @default.
• W2996548110 hasAuthorship W2996548110A5013567310 @default.
• W2996548110 hasAuthorship W2996548110A5015495373 @default.
• W2996548110 hasAuthorship W2996548110A5028833917 @default.
• W2996548110 hasAuthorship W2996548110A5032416661 @default.
• W2996548110 hasAuthorship W2996548110A5050095757 @default.
• W2996548110 hasAuthorship W2996548110A5057980545 @default.
• W2996548110 hasAuthorship W2996548110A5063267291 @default.
• W2996548110 hasAuthorship W2996548110A5069083414 @default.
• W2996548110 hasAuthorship W2996548110A5071270770 @default.
• W2996548110 hasAuthorship W2996548110A5080817499 @default.
• W2996548110 hasConcept C105702510 @default.
• W2996548110 hasConcept C136229726 @default.
• W2996548110 hasConcept C141071460 @default.
• W2996548110 hasConcept C142724271 @default.
• W2996548110 hasConcept C171056886 @default.
• W2996548110 hasConcept C204232928 @default.
• W2996548110 hasConcept C2776030733 @default.
• W2996548110 hasConcept C2776511800 @default.
• W2996548110 hasConcept C2780105995 @default.
• W2996548110 hasConcept C2780550940 @default.
• W2996548110 hasConcept C4224716 @default.
• W2996548110 hasConcept C49892992 @default.
• W2996548110 hasConcept C57742111 @default.
• W2996548110 hasConcept C68312169 @default.
• W2996548110 hasConcept C71924100 @default.
• W2996548110 hasConcept C86803240 @default.
• W2996548110 hasConcept C89429830 @default.
• W2996548110 hasConcept C95444343 @default.
• W2996548110 hasConceptScore W2996548110C105702510 @default.
• W2996548110 hasConceptScore W2996548110C136229726 @default.
• W2996548110 hasConceptScore W2996548110C141071460 @default.
• W2996548110 hasConceptScore W2996548110C142724271 @default.
• W2996548110 hasConceptScore W2996548110C171056886 @default.
• W2996548110 hasConceptScore W2996548110C204232928 @default.
• W2996548110 hasConceptScore W2996548110C2776030733 @default.
• W2996548110 hasConceptScore W2996548110C2776511800 @default.
• W2996548110 hasConceptScore W2996548110C2780105995 @default.
• W2996548110 hasConceptScore W2996548110C2780550940 @default.
• W2996548110 hasConceptScore W2996548110C4224716 @default.

• next