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- W2996601614 abstract "Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier to cellular reprogramming. It remains obscure how heterochromatin remodeling is orchestrated during cell differentiation. Here we find that the evolutionarily conserved homeodomain transcription factor Prospero (Pros)/Prox1 ensures neuronal differentiation by driving heterochromatin domain condensation and expansion. Intriguingly, in mitotically dividing Drosophila neural precursors, Pros is retained at H3K9me3+ pericentromeric heterochromatin regions of chromosomes via liquid-liquid phase separation (LLPS). During mitotic exit of neural precursors, mitotically retained Pros recruits and concentrates heterochromatin protein 1 (HP1) into phase-separated condensates and drives heterochromatin compaction. This establishes a transcriptionally repressive chromatin environment that guarantees cell-cycle exit and terminal neuronal differentiation. Importantly, mammalian Prox1 employs a similar mitotic-implantation-ensured heterochromatin condensation strategy to reinforce neuronal differentiation. Together, our results unveiled a new paradigm whereby mitotic implantation of a transcription factor via LLPS remodels H3K9me3+ heterochromatin and drives timely and irreversible terminal differentiation." @default.
- W2996601614 created "2019-12-26" @default.
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- W2996601614 date "2020-02-01" @default.
- W2996601614 modified "2023-10-12" @default.
- W2996601614 title "Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation" @default.
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- W2996601614 doi "https://doi.org/10.1016/j.devcel.2019.11.019" @default.
- W2996601614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31866201" @default.
- W2996601614 hasPublicationYear "2020" @default.
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