Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996602662> ?p ?o ?g. }
- W2996602662 abstract "ABSTRACT A large number of HIV-1 integrase (IN) alterations, referred to as class II substitutions, exhibit pleotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of three distinct mechanisms: i) markedly reducing IN levels thus precluding formation of IN complexes with viral RNA; ii) adversely affecting functional IN multimerization and consequently impairing IN binding to viral RNA; iii) directly compromising IN-RNA interactions without substantially affecting IN levels or functional IN multimerization. Inhibition of IN-RNA interactions resulted in mislocalization of the viral ribonucleoprotein complexes outside the capsid lattice, which led to premature degradation of the viral genome and IN in target cells. Collectively, our studies uncover causal mechanisms for the class II phenotype and highlight an essential role of IN-RNA interactions for accurate virion maturation." @default.
- W2996602662 created "2019-12-26" @default.
- W2996602662 creator A5001969147 @default.
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- W2996602662 creator A5020285725 @default.
- W2996602662 creator A5022448862 @default.
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- W2996602662 creator A5072685090 @default.
- W2996602662 creator A5089479264 @default.
- W2996602662 date "2019-12-19" @default.
- W2996602662 modified "2023-10-18" @default.
- W2996602662 title "Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis" @default.
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