FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996604018> ?p ?o ?g. }

• W2996604018 endingPage "726" @default.
• W2996604018 startingPage "712" @default.
• W2996604018 abstract "Angiotensin II (Ang II) levels are elevated in patients with chronic kidney disease or heart failure, and directly causes skeletal muscle wasting in rodents, but the molecular mechanisms of Ang II-induced skeletal muscle wasting and its potential as a therapeutic target are unknown. We investigated the NLR family pyrin domain containing 3 (NLRP3) inflammasome-mediated muscle atrophy response to Ang II in C2C12 myotubes and Nlrp3 knockout mice. We also assessed the mitochondrial dysfunction (MtD)/NLRP3 inflammasome axis in Ang II-induced C2C12 myotubes. Finally, we examined whether a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist could attenuate skeletal muscle wasting by targeting the MtD/NLRP3 inflammasome axis in vitro and in vivo. We demonstrated that Ang II increased NLRP3 inflammasome activation in cultured C2C12 myotubes dose dependently. Nlrp3 knockdown or Nlrp3−/− mice were protected from the imbalance of protein synthesis and degradation. Exposure of C2C12 to Ang II increased mitochondrial ROS (mtROS) generation, accompanied by MtD. Remarkably, the mitochondrial-targeted antioxidant not only decreased mtROS and MtD, it also significantly inhibited NLRP3 inflammasome activation and restored skeletal muscle atrophy. Finally, the PPAR-γ agonist protected against Ang II-induced muscle wasting by preventing MtD, oxidative stress, and NLRP3 inflammasome activation in vitro and in vivo. This work suggests a potential role of MtD/NLRP3 inflammasome pathway in the pathogenesis of Ang II-induced skeletal muscle wasting, and targeting the PPAR-γ/MtD/NLRP3 inflammasome axis may provide a therapeutic approach for muscle wasting." @default.
• W2996604018 created "2019-12-26" @default.
• W2996604018 creator A5004734740 @default.
• W2996604018 creator A5016410321 @default.
• W2996604018 creator A5037828797 @default.
• W2996604018 creator A5071209944 @default.
• W2996604018 creator A5082515921 @default.
• W2996604018 date "2020-05-01" @default.
• W2996604018 modified "2023-10-16" @default.
• W2996604018 title "Mitochondrial dysfunction/NLRP3 inflammasome axis contributes to angiotensin II-induced skeletal muscle wasting via PPAR-γ" @default.
• W2996604018 cites W1503602955 @default.
• W2996604018 cites W1511076563 @default.
• W2996604018 cites W1970403178 @default.
• W2996604018 cites W1972108813 @default.
• W2996604018 cites W1973595217 @default.
• W2996604018 cites W1974909493 @default.
• W2996604018 cites W1994971530 @default.
• W2996604018 cites W1998867833 @default.
• W2996604018 cites W2009004909 @default.
• W2996604018 cites W2012210949 @default.
• W2996604018 cites W2013900793 @default.
• W2996604018 cites W2028043263 @default.
• W2996604018 cites W2029195231 @default.
• W2996604018 cites W2035618810 @default.
• W2996604018 cites W2057518657 @default.
• W2996604018 cites W2078525354 @default.
• W2996604018 cites W2082880149 @default.
• W2996604018 cites W2112214413 @default.
• W2996604018 cites W2116819815 @default.
• W2996604018 cites W2118847288 @default.
• W2996604018 cites W2119527577 @default.
• W2996604018 cites W2123753239 @default.
• W2996604018 cites W2134498505 @default.
• W2996604018 cites W2135788465 @default.
• W2996604018 cites W2139328007 @default.
• W2996604018 cites W2141314779 @default.
• W2996604018 cites W2153237080 @default.
• W2996604018 cites W2159753941 @default.
• W2996604018 cites W2314675892 @default.
• W2996604018 cites W2417061833 @default.
• W2996604018 cites W2587681015 @default.
• W2996604018 cites W2593936419 @default.
• W2996604018 cites W2618437561 @default.
• W2996604018 cites W2762325358 @default.
• W2996604018 cites W2765968856 @default.
• W2996604018 cites W2804669464 @default.
• W2996604018 doi "https://doi.org/10.1038/s41374-019-0355-1" @default.
• W2996604018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31857693" @default.
• W2996604018 hasPublicationYear "2020" @default.
• W2996604018 type Work @default.
• W2996604018 sameAs 2996604018 @default.
• W2996604018 citedByCount "28" @default.
• W2996604018 countsByYear W29966040182020 @default.
• W2996604018 countsByYear W29966040182021 @default.
• W2996604018 countsByYear W29966040182022 @default.
• W2996604018 countsByYear W29966040182023 @default.
• W2996604018 crossrefType "journal-article" @default.
• W2996604018 hasAuthorship W2996604018A5004734740 @default.
• W2996604018 hasAuthorship W2996604018A5016410321 @default.
• W2996604018 hasAuthorship W2996604018A5037828797 @default.
• W2996604018 hasAuthorship W2996604018A5071209944 @default.
• W2996604018 hasAuthorship W2996604018A5082515921 @default.
• W2996604018 hasBestOaLocation W29966040181 @default.
• W2996604018 hasConcept C126322002 @default.
• W2996604018 hasConcept C134018914 @default.
• W2996604018 hasConcept C170493617 @default.
• W2996604018 hasConcept C185592680 @default.
• W2996604018 hasConcept C207200792 @default.
• W2996604018 hasConcept C2776151105 @default.
• W2996604018 hasConcept C2776263037 @default.
• W2996604018 hasConcept C2777209026 @default.
• W2996604018 hasConcept C2778175917 @default.
• W2996604018 hasConcept C2779959927 @default.
• W2996604018 hasConcept C28859421 @default.
• W2996604018 hasConcept C2908929049 @default.
• W2996604018 hasConcept C3763915 @default.
• W2996604018 hasConcept C71924100 @default.
• W2996604018 hasConcept C86803240 @default.
• W2996604018 hasConcept C95444343 @default.
• W2996604018 hasConceptScore W2996604018C126322002 @default.
• W2996604018 hasConceptScore W2996604018C134018914 @default.
• W2996604018 hasConceptScore W2996604018C170493617 @default.
• W2996604018 hasConceptScore W2996604018C185592680 @default.
• W2996604018 hasConceptScore W2996604018C207200792 @default.
• W2996604018 hasConceptScore W2996604018C2776151105 @default.
• W2996604018 hasConceptScore W2996604018C2776263037 @default.
• W2996604018 hasConceptScore W2996604018C2777209026 @default.
• W2996604018 hasConceptScore W2996604018C2778175917 @default.
• W2996604018 hasConceptScore W2996604018C2779959927 @default.
• W2996604018 hasConceptScore W2996604018C28859421 @default.
• W2996604018 hasConceptScore W2996604018C2908929049 @default.
• W2996604018 hasConceptScore W2996604018C3763915 @default.
• W2996604018 hasConceptScore W2996604018C71924100 @default.
• W2996604018 hasConceptScore W2996604018C86803240 @default.
• W2996604018 hasConceptScore W2996604018C95444343 @default.
• W2996604018 hasIssue "5" @default.
• W2996604018 hasLocation W29966040181 @default.
• W2996604018 hasLocation W29966040182 @default.

• next