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- W2996632475 endingPage "54" @default.
- W2996632475 startingPage "45" @default.
- W2996632475 abstract "There are several pulmonary hypertensive diseases that affect the neonatal population, including persistent pulmonary hypertension of the newborn (PPHN) and bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). While the indication for inhaled nitric oxide (iNO) use is for late-preterm and term neonates with PPHN, there is a suboptimal response to this pulmonary vasodilator in ~40% of patients. Additionally, there are no FDA-approved treatments for BPD-associated PH or for preterm infants with PH. Therefore, investigating mechanisms that alter the nitric oxide-signaling pathway has been at the forefront of pulmonary vascular biology research. In this review, we will discuss the various mechanistic pathways that have been targets in neonatal PH, including NO precursors, soluble guanylate cyclase modulators, phosphodiesterase inhibitors and antioxidants. We will review their role in enhancing NO-signaling at the bench, in animal models, as well as highlight their role in the treatment of neonates with PH." @default.
- W2996632475 created "2019-12-26" @default.
- W2996632475 creator A5013969291 @default.
- W2996632475 creator A5025837132 @default.
- W2996632475 creator A5077701476 @default.
- W2996632475 date "2020-02-01" @default.
- W2996632475 modified "2023-10-11" @default.
- W2996632475 title "Therapies that enhance pulmonary vascular NO-signaling in the neonate" @default.
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