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- W2996644443 abstract "Naturally transformable, or competent, bacteria are able to take up DNA from their environment, a key method of horizontal gene transfer for acquisition of new DNA sequences. Our research shows that Vibrio species that inhabit marine environments exhibit a wide diversity in natural transformation capability ranging from nontransformability to high transformation rates in which 10% of cells measurably incorporate new DNA. We show that the role of regulatory systems controlling the expression of competence genes (e.g., quorum sensing) differs throughout both the species and strain levels. We explore natural transformation capabilities of Vibrio campbellii species which have been thus far uncharacterized and find novel regulation of competence. Expression of two key transcription factors, TfoX and QstR, is necessary to stimulate high levels of transformation in Vibrio campbellii and recover low rates of transformation in Vibrio vulnificus ." @default.
- W2996644443 created "2019-12-26" @default.
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- W2996644443 date "2019-12-24" @default.
- W2996644443 modified "2023-09-27" @default.
- W2996644443 title "Diversity in Natural Transformation Frequencies and Regulation across <i>Vibrio</i> Species" @default.
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- W2996644443 doi "https://doi.org/10.1128/mbio.02788-19" @default.
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