FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996654920> ?p ?o ?g. }

• W2996654920 abstract "Scope Recent evidences demonstrate that abnormal gut microbiota (GM) might be involved in the pathogenesis of Alzheimer's disease (AD). However, the role of probiotics in preventing AD by regulating GM–gut–brain axis remains unclear. Here, the anti‐neuroinflammatory effect and its mechanism of probiotic Clostridium butyricum (CB) against AD is investigated by regulating GM–gut–brain axis. Methods and results APPswe/PS1dE9 (APP/PS1) transgenic are treated intragastrically with CB for 4 weeks then cognitively tested. Amyloid‐β (Aβ) burden, microglial activation, proinflammatory cytokines production, GM, and metabolites butyrate are analyzed. Moreover, Aβ‐induced BV2 microglia are pretreated with butyrate, and the levels of cluster of differentiation 11b (CD11b), cyclooxygenase‐2 (COX‐2), and NF‐κB p65 phosphorylation are determined. The results show that CB treatment prevents cognitive impairment, Aβ deposits, microglia activation, and production of tumor necrosis factor (TNF)‐α and interleukin (IL)‐1β in the brain of APP/PS1 mice. Meanwhile, abnormal GM and butyrate are reversed after CB treatment. Notably, butyrate treatment reduces the levels of CD11b and COX‐2, and suppresses phosphorylation of NF‐κB p65 in the Aβ‐induced BV2 microglia. Conclusions These findings indicate that CB treatment could attenuate microglia‐mediated neuroinflammation via regulating the GM–gut–brain axis, which is mediated by the metabolite butyrate." @default.
• W2996654920 created "2019-12-26" @default.
• W2996654920 creator A5003094236 @default.
• W2996654920 creator A5003408687 @default.
• W2996654920 creator A5016554833 @default.
• W2996654920 creator A5024093685 @default.
• W2996654920 creator A5034925373 @default.
• W2996654920 creator A5037322205 @default.
• W2996654920 creator A5057839636 @default.
• W2996654920 creator A5076370858 @default.
• W2996654920 creator A5082561375 @default.
• W2996654920 creator A5084374323 @default.
• W2996654920 date "2019-12-23" @default.
• W2996654920 modified "2023-10-16" @default.
• W2996654920 title "Effect of <i>Clostridium butyricum</i> against Microglia‐Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate" @default.
• W2996654920 cites W1492795942 @default.
• W2996654920 cites W1515023627 @default.
• W2996654920 cites W1968786165 @default.
• W2996654920 cites W1995721152 @default.
• W2996654920 cites W2019495623 @default.
• W2996654920 cites W2028170458 @default.
• W2996654920 cites W2040556005 @default.
• W2996654920 cites W2046865462 @default.
• W2996654920 cites W2096407545 @default.
• W2996654920 cites W2114102190 @default.
• W2996654920 cites W2166562121 @default.
• W2996654920 cites W2167291570 @default.
• W2996654920 cites W2168117082 @default.
• W2996654920 cites W2205716366 @default.
• W2996654920 cites W2228779853 @default.
• W2996654920 cites W2300911794 @default.
• W2996654920 cites W2302886547 @default.
• W2996654920 cites W2317525803 @default.
• W2996654920 cites W2323865999 @default.
• W2996654920 cites W2409725256 @default.
• W2996654920 cites W2473313158 @default.
• W2996654920 cites W2508213551 @default.
• W2996654920 cites W2519408637 @default.
• W2996654920 cites W2523727887 @default.
• W2996654920 cites W2558599134 @default.
• W2996654920 cites W2747276149 @default.
• W2996654920 cites W2751989552 @default.
• W2996654920 cites W2761210275 @default.
• W2996654920 cites W2762048636 @default.
• W2996654920 cites W2766240266 @default.
• W2996654920 cites W2768364576 @default.
• W2996654920 cites W2774851697 @default.
• W2996654920 cites W2787750161 @default.
• W2996654920 cites W2790289132 @default.
• W2996654920 cites W2799884346 @default.
• W2996654920 cites W2883931951 @default.
• W2996654920 cites W2886360969 @default.
• W2996654920 cites W2889932986 @default.
• W2996654920 cites W2893554173 @default.
• W2996654920 cites W2896131310 @default.
• W2996654920 cites W2900756684 @default.
• W2996654920 cites W2920086083 @default.
• W2996654920 cites W2921781039 @default.
• W2996654920 cites W2955664060 @default.
• W2996654920 cites W2965398438 @default.
• W2996654920 cites W2967674535 @default.
• W2996654920 cites W4293388891 @default.
• W2996654920 doi "https://doi.org/10.1002/mnfr.201900636" @default.
• W2996654920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31835282" @default.
• W2996654920 hasPublicationYear "2019" @default.
• W2996654920 type Work @default.
• W2996654920 sameAs 2996654920 @default.
• W2996654920 citedByCount "123" @default.
• W2996654920 countsByYear W29966549202020 @default.
• W2996654920 countsByYear W29966549202021 @default.
• W2996654920 countsByYear W29966549202022 @default.
• W2996654920 countsByYear W29966549202023 @default.
• W2996654920 crossrefType "journal-article" @default.
• W2996654920 hasAuthorship W2996654920A5003094236 @default.
• W2996654920 hasAuthorship W2996654920A5003408687 @default.
• W2996654920 hasAuthorship W2996654920A5016554833 @default.
• W2996654920 hasAuthorship W2996654920A5024093685 @default.
• W2996654920 hasAuthorship W2996654920A5034925373 @default.
• W2996654920 hasAuthorship W2996654920A5037322205 @default.
• W2996654920 hasAuthorship W2996654920A5057839636 @default.
• W2996654920 hasAuthorship W2996654920A5076370858 @default.
• W2996654920 hasAuthorship W2996654920A5082561375 @default.
• W2996654920 hasAuthorship W2996654920A5084374323 @default.
• W2996654920 hasConcept C100544194 @default.
• W2996654920 hasConcept C164027704 @default.
• W2996654920 hasConcept C177857423 @default.
• W2996654920 hasConcept C17991360 @default.
• W2996654920 hasConcept C185592680 @default.
• W2996654920 hasConcept C203014093 @default.
• W2996654920 hasConcept C2776914184 @default.
• W2996654920 hasConcept C2776979534 @default.
• W2996654920 hasConcept C2777261523 @default.
• W2996654920 hasConcept C2779830541 @default.
• W2996654920 hasConcept C539455810 @default.
• W2996654920 hasConcept C55493867 @default.
• W2996654920 hasConcept C86803240 @default.
• W2996654920 hasConcept C87753298 @default.
• W2996654920 hasConceptScore W2996654920C100544194 @default.
• W2996654920 hasConceptScore W2996654920C164027704 @default.
• W2996654920 hasConceptScore W2996654920C177857423 @default.

• next