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• W2996722363 endingPage "117955141988887" @default.
• W2996722363 startingPage "117955141988887" @default.
• W2996722363 abstract "The pancreas has physiologically important endocrine and exocrine functions; secreting enzymes into the small intestine to aid digestion and releasing multiple peptide hormones via the islets of Langerhans to regulate glucose metabolism, respectively. Insulin and glucagon, in combination with ghrelin, pancreatic polypeptide and somatostatin, are the main classical islet peptides critical for the maintenance of blood glucose. However, pancreatic islets also synthesis numerous ‘nonclassical’ peptides that have recently been demonstrated to exert fundamental effects on overall islet function and metabolism. As such, insights into the physiological relevance of these nonclassical peptides have shown impact on glucose metabolism, insulin action, cell survival, weight loss, and energy expenditure. This review will focus on the role of individual nonclassical islet peptides to stimulate pancreatic islet secretions as well as regulate metabolism. In addition, the more recognised actions of these peptides on satiety and energy regulation will also be considered. Furthermore, recent advances in the field of peptide therapeutics and obesity-diabetes have focused on the benefits of simultaneously targeting several hormone receptor signalling cascades. The potential for nonclassical islet hormones within such combinational approaches will also be discussed." @default.
• W2996722363 created "2019-12-26" @default.
• W2996722363 creator A5001545372 @default.
• W2996722363 creator A5073410539 @default.
• W2996722363 date "2019-01-01" @default.
• W2996722363 modified "2023-10-17" @default.
• W2996722363 title "Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions" @default.
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