FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996727859> ?p ?o ?g. }

• W2996727859 abstract "Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons (MNs) during late adulthood. Here, with the aim of identifying early changes underpinning ALS neurodegeneration, we analyzed the GABAergic/glycinergic inputs to E17.5 fetal MNs from SOD1G93A (SOD) mice in parallel with chloride homeostasis. Our results show that IPSCs are less frequent in SOD animals in accordance with a reduction of synaptic VIAAT-positive terminals. SOD MNs exhibited an EGABAAR10 mV more depolarized than in WT MNs associated with a KCC2 reduction. Interestingly, SOD GABAergic/glycinergic IPSCs and evoked GABAAR-currents exhibited a slower decay correlated to elevated [Cl-]i. Computer simulations revealed that a slower relaxation of synaptic inhibitory events acts as compensatory mechanism to strengthen GABA/glycine inhibition when EGABAAR is more depolarized. How such mechanisms evolve during pathophysiological processes remain to be determined, but our data indicate that at least SOD1 familial ALS may be considered as a neurodevelopmental disease." @default.
• W2996727859 created "2019-12-26" @default.
• W2996727859 creator A5017772062 @default.
• W2996727859 creator A5025365588 @default.
• W2996727859 creator A5028696869 @default.
• W2996727859 creator A5044700245 @default.
• W2996727859 creator A5053443189 @default.
• W2996727859 creator A5068737615 @default.
• W2996727859 creator A5076638874 @default.
• W2996727859 creator A5083503377 @default.
• W2996727859 creator A5087807883 @default.
• W2996727859 creator A5089703269 @default.
• W2996727859 date "2019-12-23" @default.
• W2996727859 modified "2023-10-13" @default.
• W2996727859 title "Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks" @default.
• W2996727859 cites W1588629441 @default.
• W2996727859 cites W1607372012 @default.
• W2996727859 cites W1844869729 @default.
• W2996727859 cites W1852853462 @default.
• W2996727859 cites W1872543256 @default.
• W2996727859 cites W1884110331 @default.
• W2996727859 cites W1942615418 @default.
• W2996727859 cites W1974914532 @default.
• W2996727859 cites W1977211415 @default.
• W2996727859 cites W1981111905 @default.
• W2996727859 cites W1981182334 @default.
• W2996727859 cites W1986315354 @default.
• W2996727859 cites W1989659293 @default.
• W2996727859 cites W1992169439 @default.
• W2996727859 cites W1994252481 @default.
• W2996727859 cites W1995137108 @default.
• W2996727859 cites W1995441615 @default.
• W2996727859 cites W1995831678 @default.
• W2996727859 cites W2001432662 @default.
• W2996727859 cites W2014310721 @default.
• W2996727859 cites W2019909157 @default.
• W2996727859 cites W2026372988 @default.
• W2996727859 cites W2029036884 @default.
• W2996727859 cites W2031781097 @default.
• W2996727859 cites W2039829972 @default.
• W2996727859 cites W2043683966 @default.
• W2996727859 cites W2045132169 @default.
• W2996727859 cites W2047239277 @default.
• W2996727859 cites W2047867249 @default.
• W2996727859 cites W2050582164 @default.
• W2996727859 cites W2050996013 @default.
• W2996727859 cites W2052405932 @default.
• W2996727859 cites W2053867740 @default.
• W2996727859 cites W2055336709 @default.
• W2996727859 cites W2056300681 @default.
• W2996727859 cites W2057724638 @default.
• W2996727859 cites W2057759463 @default.
• W2996727859 cites W2072492494 @default.
• W2996727859 cites W2072808488 @default.
• W2996727859 cites W2085204538 @default.
• W2996727859 cites W2099036911 @default.
• W2996727859 cites W2107065376 @default.
• W2996727859 cites W2114088312 @default.
• W2996727859 cites W2117120818 @default.
• W2996727859 cites W2123003659 @default.
• W2996727859 cites W2133232170 @default.
• W2996727859 cites W2141587041 @default.
• W2996727859 cites W2151916462 @default.
• W2996727859 cites W2154875971 @default.
• W2996727859 cites W2157076525 @default.
• W2996727859 cites W2158738489 @default.
• W2996727859 cites W2168779967 @default.
• W2996727859 cites W2169604722 @default.
• W2996727859 cites W2186788982 @default.
• W2996727859 cites W2219548386 @default.
• W2996727859 cites W2278934127 @default.
• W2996727859 cites W2301435056 @default.
• W2996727859 cites W2309588686 @default.
• W2996727859 cites W2325907993 @default.
• W2996727859 cites W2342889336 @default.
• W2996727859 cites W2346143475 @default.
• W2996727859 cites W2461540919 @default.
• W2996727859 cites W2467267481 @default.
• W2996727859 cites W2611815300 @default.
• W2996727859 cites W2725586270 @default.
• W2996727859 cites W2784999381 @default.
• W2996727859 cites W2795946227 @default.
• W2996727859 cites W2807023793 @default.
• W2996727859 cites W2890533887 @default.
• W2996727859 cites W2894860397 @default.
• W2996727859 cites W4214775604 @default.
• W2996727859 doi "https://doi.org/10.7554/elife.51402" @default.
• W2996727859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6974356" @default.
• W2996727859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31868588" @default.
• W2996727859 hasPublicationYear "2019" @default.
• W2996727859 type Work @default.
• W2996727859 sameAs 2996727859 @default.
• W2996727859 citedByCount "12" @default.
• W2996727859 countsByYear W29967278592020 @default.
• W2996727859 countsByYear W29967278592021 @default.
• W2996727859 countsByYear W29967278592022 @default.
• W2996727859 countsByYear W29967278592023 @default.
• W2996727859 crossrefType "journal-article" @default.
• W2996727859 hasAuthorship W2996727859A5017772062 @default.
• W2996727859 hasAuthorship W2996727859A5025365588 @default.

• next