Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996751281> ?p ?o ?g. }
- W2996751281 endingPage "109985" @default.
- W2996751281 startingPage "109985" @default.
- W2996751281 abstract "Effort has been made to standardise regulatory ecotoxicity tests for engineered nanomaterials (ENMs), but the environmental realism of altered water quality and/or pulse exposure to these pollutants should be considered. This study aimed to investigate the relative toxicity to early life-stage zebrafish of CuO ENMs at acid pH and then under pulse exposure conditions, all compared to CuSO4. At all pH values, CuSO4 was more toxic to zebrafish than CuO ENMs. Additions of H+ were protective of CuSO4 toxicity, with median lethal concentrations LC50 (with 95% confidence intervals) of: 0.36 (0.33–0.40), 0.22 (0.20–0.24) and 0.27 (0.25–0.29) mg L−1 at pH 5, pH 6 and pH 7, respectively. In contrast, the toxicity of CuO ENMs increased with acidity; LC50 values were: 6.6 (4.5–8.5), 19.4 (11.6–27.2) and >100 mg L−1 at pH 5, pH 6 and pH 7, respectively. The increased toxicity of the CuO ENMs in acid water corresponded with greater dissolution of dissolved Cu from the particles at low pH, suggesting free Cu2+ ion delivery to the zebrafish was responsible for the pH-effect. In continuous 96 h exposures to the substances at the LC10 values and at pH 6, both CuSO4 and CuO ENMs caused Cu accumulation, inhibition of Na+/K+-ATPase and depletion of total glutathione in zebrafish. However, two 24 h pulses of CuSO4 or CuO ENMs at the same peak concentration caused similar effects to the continuous 96 h exposure, despite the shorter exposure durations of the former; suggesting that the pulses were more hazardous than the continuous exposure. In conclusion, the current water quality correction for pH with respect to Cu toxicity to freshwater fish should not be applied to the nano form. Crucially, CuO ENMs are more toxic in pulse than continuous exposure and new corrections for both water pH and the Cu exposure profile are needed for environmental risk assessment." @default.
- W2996751281 created "2019-12-26" @default.
- W2996751281 creator A5019264666 @default.
- W2996751281 creator A5021836140 @default.
- W2996751281 creator A5041196638 @default.
- W2996751281 date "2020-03-01" @default.
- W2996751281 modified "2023-09-25" @default.
- W2996751281 title "Toxicities of copper oxide nanomaterial and copper sulphate in early life stage zebrafish: Effects of pH and intermittent pulse exposure" @default.
- W2996751281 cites W1857370090 @default.
- W2996751281 cites W1966171945 @default.
- W2996751281 cites W1967133409 @default.
- W2996751281 cites W1978988949 @default.
- W2996751281 cites W1984087363 @default.
- W2996751281 cites W1986437187 @default.
- W2996751281 cites W1991273560 @default.
- W2996751281 cites W1992308215 @default.
- W2996751281 cites W2015787831 @default.
- W2996751281 cites W2023294979 @default.
- W2996751281 cites W2027675005 @default.
- W2996751281 cites W2033285594 @default.
- W2996751281 cites W2039465618 @default.
- W2996751281 cites W2043886709 @default.
- W2996751281 cites W2046578001 @default.
- W2996751281 cites W2049426807 @default.
- W2996751281 cites W2049992079 @default.
- W2996751281 cites W2052159857 @default.
- W2996751281 cites W2054514771 @default.
- W2996751281 cites W2067628478 @default.
- W2996751281 cites W2077510942 @default.
- W2996751281 cites W2094256664 @default.
- W2996751281 cites W2097859905 @default.
- W2996751281 cites W2100049001 @default.
- W2996751281 cites W2104273489 @default.
- W2996751281 cites W2124250994 @default.
- W2996751281 cites W2161394832 @default.
- W2996751281 cites W2276888196 @default.
- W2996751281 cites W2277871178 @default.
- W2996751281 cites W2321814792 @default.
- W2996751281 cites W2325699440 @default.
- W2996751281 cites W2433022886 @default.
- W2996751281 cites W2472083348 @default.
- W2996751281 cites W2528181599 @default.
- W2996751281 cites W2557916856 @default.
- W2996751281 cites W2563842177 @default.
- W2996751281 cites W2588669779 @default.
- W2996751281 cites W2623949428 @default.
- W2996751281 cites W2762226159 @default.
- W2996751281 cites W2769191167 @default.
- W2996751281 cites W2796305066 @default.
- W2996751281 cites W2796677628 @default.
- W2996751281 cites W2885609179 @default.
- W2996751281 cites W2895041363 @default.
- W2996751281 cites W2898302523 @default.
- W2996751281 cites W2915050543 @default.
- W2996751281 doi "https://doi.org/10.1016/j.ecoenv.2019.109985" @default.
- W2996751281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31841893" @default.
- W2996751281 hasPublicationYear "2020" @default.
- W2996751281 type Work @default.
- W2996751281 sameAs 2996751281 @default.
- W2996751281 citedByCount "31" @default.
- W2996751281 countsByYear W29967512812020 @default.
- W2996751281 countsByYear W29967512812021 @default.
- W2996751281 countsByYear W29967512812022 @default.
- W2996751281 countsByYear W29967512812023 @default.
- W2996751281 crossrefType "journal-article" @default.
- W2996751281 hasAuthorship W2996751281A5019264666 @default.
- W2996751281 hasAuthorship W2996751281A5021836140 @default.
- W2996751281 hasAuthorship W2996751281A5041196638 @default.
- W2996751281 hasBestOaLocation W29967512812 @default.
- W2996751281 hasConcept C107872376 @default.
- W2996751281 hasConcept C13965031 @default.
- W2996751281 hasConcept C178790620 @default.
- W2996751281 hasConcept C181199279 @default.
- W2996751281 hasConcept C185592680 @default.
- W2996751281 hasConcept C2778404011 @default.
- W2996751281 hasConcept C29730261 @default.
- W2996751281 hasConcept C46797941 @default.
- W2996751281 hasConcept C538909803 @default.
- W2996751281 hasConcept C544778455 @default.
- W2996751281 hasConcept C55493867 @default.
- W2996751281 hasConcept C82685317 @default.
- W2996751281 hasConceptScore W2996751281C107872376 @default.
- W2996751281 hasConceptScore W2996751281C13965031 @default.
- W2996751281 hasConceptScore W2996751281C178790620 @default.
- W2996751281 hasConceptScore W2996751281C181199279 @default.
- W2996751281 hasConceptScore W2996751281C185592680 @default.
- W2996751281 hasConceptScore W2996751281C2778404011 @default.
- W2996751281 hasConceptScore W2996751281C29730261 @default.
- W2996751281 hasConceptScore W2996751281C46797941 @default.
- W2996751281 hasConceptScore W2996751281C538909803 @default.
- W2996751281 hasConceptScore W2996751281C544778455 @default.
- W2996751281 hasConceptScore W2996751281C55493867 @default.
- W2996751281 hasConceptScore W2996751281C82685317 @default.
- W2996751281 hasFunder F4320320300 @default.
- W2996751281 hasFunder F4320322523 @default.
- W2996751281 hasLocation W29967512811 @default.
- W2996751281 hasLocation W29967512812 @default.
- W2996751281 hasLocation W29967512813 @default.