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- W2996801636 endingPage "1357" @default.
- W2996801636 startingPage "1350" @default.
- W2996801636 abstract "Selective suppression of graft rejection while maintaining anti-pathogen responses has been elusive. Thus far, the most successful strategies to induce suppression of graft rejection relies on inhibition of T-cell activation. However, the very same mechanisms that induce allograft-specific T-cell suppression are also important for immunity against microbial pathogens as well as oncogenically transformed cells, resulting in significant immunosuppression-associated comorbidities. Therefore, defining the pathways that differentially regulate anti-graft versus antimicrobial T-cell responses may allow the development of regimen to induce allograft-specific tolerance. Recent work has defined a molecular pathway driven by the immunoregulatory protein coronin 1 that regulates the phosphodiesterase/cyclic adenosine monophosphate pathway and modulates T cell responses. Interestingly, disruption of coronin 1 promotes allograft tolerance while immunity towards a range of pathogenic microbes is maintained. Here, we briefly review the work leading up to these findings as well as their possible implications for transplantation medicine." @default.
- W2996801636 created "2020-01-10" @default.
- W2996801636 creator A5044213528 @default.
- W2996801636 creator A5055195241 @default.
- W2996801636 date "2019-12-30" @default.
- W2996801636 modified "2023-09-26" @default.
- W2996801636 title "Induction of Allograft Tolerance While Maintaining Immunity Against Microbial Pathogens: Does Coronin 1 Hold a Key?" @default.
- W2996801636 cites W1492775073 @default.
- W2996801636 cites W1501307290 @default.
- W2996801636 cites W1520337017 @default.
- W2996801636 cites W1573740779 @default.
- W2996801636 cites W1670479168 @default.
- W2996801636 cites W1751257529 @default.
- W2996801636 cites W1946381923 @default.
- W2996801636 cites W1963574332 @default.
- W2996801636 cites W1965572078 @default.
- W2996801636 cites W1967359666 @default.
- W2996801636 cites W1967851170 @default.
- W2996801636 cites W1970276280 @default.
- W2996801636 cites W1972153484 @default.
- W2996801636 cites W1972647838 @default.
- W2996801636 cites W1979353700 @default.
- W2996801636 cites W1982155401 @default.
- W2996801636 cites W2002386322 @default.
- W2996801636 cites W2005806944 @default.
- W2996801636 cites W2005871909 @default.
- W2996801636 cites W2022304096 @default.
- W2996801636 cites W2022878394 @default.
- W2996801636 cites W2023314253 @default.
- W2996801636 cites W2024398910 @default.
- W2996801636 cites W2025529779 @default.
- W2996801636 cites W2026468762 @default.
- W2996801636 cites W2031658302 @default.
- W2996801636 cites W2032629491 @default.
- W2996801636 cites W2036749164 @default.
- W2996801636 cites W2041869966 @default.
- W2996801636 cites W2043433501 @default.
- W2996801636 cites W2045254177 @default.
- W2996801636 cites W2045381482 @default.
- W2996801636 cites W2048492877 @default.
- W2996801636 cites W2049374415 @default.
- W2996801636 cites W2049776359 @default.
- W2996801636 cites W2055598277 @default.
- W2996801636 cites W2056519855 @default.
- W2996801636 cites W2057648030 @default.
- W2996801636 cites W2062409682 @default.
- W2996801636 cites W2063645026 @default.
- W2996801636 cites W2064164710 @default.
- W2996801636 cites W2068046091 @default.
- W2996801636 cites W2070673054 @default.
- W2996801636 cites W2074321172 @default.
- W2996801636 cites W2077767341 @default.
- W2996801636 cites W2080875376 @default.
- W2996801636 cites W2081632953 @default.
- W2996801636 cites W2082476464 @default.
- W2996801636 cites W2089676458 @default.
- W2996801636 cites W2090334210 @default.
- W2996801636 cites W2097479331 @default.
- W2996801636 cites W2104479866 @default.
- W2996801636 cites W2106621815 @default.
- W2996801636 cites W2107383854 @default.
- W2996801636 cites W2107529713 @default.
- W2996801636 cites W2107841942 @default.
- W2996801636 cites W2108454894 @default.
- W2996801636 cites W2113202132 @default.
- W2996801636 cites W2114737175 @default.
- W2996801636 cites W2115767669 @default.
- W2996801636 cites W2126244930 @default.
- W2996801636 cites W2126312769 @default.
- W2996801636 cites W2131784571 @default.
- W2996801636 cites W2131876870 @default.
- W2996801636 cites W2132909461 @default.
- W2996801636 cites W2134672034 @default.
- W2996801636 cites W2151667260 @default.
- W2996801636 cites W2156194752 @default.
- W2996801636 cites W2162228918 @default.
- W2996801636 cites W2164736972 @default.
- W2996801636 cites W2166305071 @default.
- W2996801636 cites W2169118161 @default.
- W2996801636 cites W2170355588 @default.
- W2996801636 cites W2221307589 @default.
- W2996801636 cites W2288346340 @default.
- W2996801636 cites W2299038626 @default.
- W2996801636 cites W2303852857 @default.
- W2996801636 cites W2306516798 @default.
- W2996801636 cites W2329012680 @default.
- W2996801636 cites W2334461518 @default.
- W2996801636 cites W2415052762 @default.
- W2996801636 cites W2462460461 @default.
- W2996801636 cites W2473826479 @default.
- W2996801636 cites W2518144822 @default.
- W2996801636 cites W2750557185 @default.
- W2996801636 cites W2775663182 @default.
- W2996801636 cites W2789792211 @default.
- W2996801636 cites W2810752391 @default.
- W2996801636 cites W2897406695 @default.
- W2996801636 cites W2906782400 @default.
- W2996801636 cites W2910911633 @default.