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• W2996810335 abstract "Purpose To examine the potential effect of CT dose variation on radiomic features in vivo using simulated contrast-enhanced CT dose reduction in patients with non-small lung cell cancer (NSCLC). Methods In this retrospective study, we included 69 patients (25 females, 44 males, median age 66 years) with histologically proven NSCLC who underwent a whole contrast-enhanced body FDG-PET/CT for primary staging. To simulate different CT dose levels, we used an algorithm to simulate low-dose CT images based on a noise model derived from phantom experiments. The tumor lesions and reference regions in the paraspinal muscle were manually segmented to obtain three-dimensional regions of interest. Radiomic feature extraction was performed using the PyRadiomics toolbox. The median relative feature value deviation was assessed for each feature and each dose level. Results The mean segmented tumor volume was 340 ml. T-stages of the primary tumors were primarily T3/4. For NSCLCs, the median relative feature value deviation in the lowest dose images varied for the calculated features from 52.2% to –49.5%. In general, dose-dependent deviations of feature values showed a monotonous increase or decrease with decreasing dose levels. Statistical analyses revealed significant differences between the dose levels in 91% of features. Conclusions We examined the effects of simulated CT dose reduction on the values of radiomic features in primary NSCLC and showed significant deviations of varying degrees in numerous feature classes. This is a theoretical indicator of potential influence under real conditions, which should be taken into account in clinical use." @default.
• W2996810335 created "2020-01-10" @default.
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• W2996810335 date "2020-03-01" @default.
• W2996810335 modified "2023-10-18" @default.
• W2996810335 title "Effects of simulated dose variation on contrast-enhanced CT-based radiomic analysis for Non-Small Cell Lung Cancer" @default.
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• W2996810335 doi "https://doi.org/10.1016/j.ejrad.2019.108804" @default.
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