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- W2996821000 endingPage "187" @default.
- W2996821000 startingPage "175" @default.
- W2996821000 abstract "Introduction: Midlife hypertension has been consistently linked with increased risk of cognitive decline and Alzheimer’s disease (AD). Observational studies and randomized trials show that the use of antihypertensive therapy is associated with a lesser incidence or prevalence of cognitive impairment and dementia. However, whether antihypertensive agents specifically target the pathological process of AD remains elusive.Areas covered: This review of literature provides an update on the clinical and preclinical arguments supporting anti-AD properties of antihypertensive drugs. The authors focused on validated all classes of antihypertensive treatments such as angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB), calcium channel blockers (CCB), β-blockers, diuretics, neprilysin inhibitors, and other agents. Three main mechanisms can be advocated: action on the concurrent vascular pathology, action on the vascular component of Alzheimer’s pathophysiology, and action on nonvascular targets.Expert opinion: In 2019, while there is no doubt that hypertension should be treated in primary prevention of vascular disease and in secondary prevention of stroke and mixed dementia, the place of antihypertensive agents in the secondary prevention of ‘pure’ AD remains an outstanding question." @default.
- W2996821000 created "2020-01-10" @default.
- W2996821000 creator A5011149562 @default.
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- W2996821000 creator A5020584849 @default.
- W2996821000 creator A5055524428 @default.
- W2996821000 creator A5079246880 @default.
- W2996821000 date "2019-12-27" @default.
- W2996821000 modified "2023-10-13" @default.
- W2996821000 title "Antihypertensive agents in Alzheimer’s disease: beyond vascular protection" @default.
- W2996821000 cites W1131579344 @default.
- W2996821000 cites W1417309998 @default.
- W2996821000 cites W1480141326 @default.
- W2996821000 cites W1495979380 @default.
- W2996821000 cites W1555597750 @default.
- W2996821000 cites W1578707359 @default.
- W2996821000 cites W1586213696 @default.
- W2996821000 cites W1671903847 @default.
- W2996821000 cites W1768716662 @default.
- W2996821000 cites W1785942725 @default.
- W2996821000 cites W1835154286 @default.
- W2996821000 cites W1967083272 @default.
- W2996821000 cites W1969514561 @default.
- W2996821000 cites W1971398866 @default.
- W2996821000 cites W1976363273 @default.
- W2996821000 cites W1977449838 @default.
- W2996821000 cites W1979370053 @default.
- W2996821000 cites W1988655607 @default.
- W2996821000 cites W1992998861 @default.
- W2996821000 cites W1994892202 @default.
- W2996821000 cites W1995517612 @default.
- W2996821000 cites W1995817686 @default.
- W2996821000 cites W1996649563 @default.
- W2996821000 cites W1999061258 @default.
- W2996821000 cites W2001082974 @default.
- W2996821000 cites W2002737245 @default.
- W2996821000 cites W2003159190 @default.
- W2996821000 cites W2003553417 @default.
- W2996821000 cites W2003816877 @default.
- W2996821000 cites W2003923036 @default.
- W2996821000 cites W2004205778 @default.
- W2996821000 cites W2006035554 @default.
- W2996821000 cites W2006450819 @default.
- W2996821000 cites W2006534012 @default.
- W2996821000 cites W2010398494 @default.
- W2996821000 cites W2017213641 @default.
- W2996821000 cites W2017288719 @default.
- W2996821000 cites W2020240430 @default.
- W2996821000 cites W2028028255 @default.
- W2996821000 cites W2029609315 @default.
- W2996821000 cites W2030011352 @default.
- W2996821000 cites W2031645622 @default.
- W2996821000 cites W2033884029 @default.
- W2996821000 cites W2038003980 @default.
- W2996821000 cites W2040905269 @default.
- W2996821000 cites W2041240420 @default.
- W2996821000 cites W2049710384 @default.
- W2996821000 cites W2051393086 @default.
- W2996821000 cites W2059878016 @default.
- W2996821000 cites W2065301205 @default.
- W2996821000 cites W2066092513 @default.
- W2996821000 cites W2066510834 @default.
- W2996821000 cites W2069140826 @default.
- W2996821000 cites W2071345353 @default.
- W2996821000 cites W2071762923 @default.
- W2996821000 cites W2072361654 @default.
- W2996821000 cites W2074708674 @default.
- W2996821000 cites W2076234773 @default.
- W2996821000 cites W2076255931 @default.
- W2996821000 cites W2076929722 @default.
- W2996821000 cites W2076948181 @default.
- W2996821000 cites W2080857041 @default.
- W2996821000 cites W2084899590 @default.
- W2996821000 cites W2085176275 @default.
- W2996821000 cites W2091652119 @default.
- W2996821000 cites W2092545090 @default.
- W2996821000 cites W2097072982 @default.
- W2996821000 cites W2097957153 @default.
- W2996821000 cites W2098706789 @default.
- W2996821000 cites W2100428051 @default.
- W2996821000 cites W2101090291 @default.
- W2996821000 cites W2104565625 @default.
- W2996821000 cites W2105127935 @default.
- W2996821000 cites W2106122924 @default.
- W2996821000 cites W2107917334 @default.
- W2996821000 cites W2110930701 @default.
- W2996821000 cites W2113698123 @default.
- W2996821000 cites W2114635452 @default.
- W2996821000 cites W2114781316 @default.
- W2996821000 cites W2116287283 @default.
- W2996821000 cites W2116630618 @default.
- W2996821000 cites W2116709840 @default.
- W2996821000 cites W2117517865 @default.
- W2996821000 cites W2117810641 @default.
- W2996821000 cites W2118997136 @default.
- W2996821000 cites W2120070267 @default.
- W2996821000 cites W2120404138 @default.
- W2996821000 cites W2122069311 @default.