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• W2996821602 abstract "The efficacy of oncolytic viruses (OVs), such as reovirus, is dictated by host immune responses, including those mediated by the pro- versus anti-inflammatory macrophages. As such, a detailed understanding of the interaction between reovirus and different macrophage types is critical for therapeutic efficacy. To explore reovirus–macrophage interactions, we performed tandem mass tag (TMT)-based quantitative temporal proteomics on mouse bone marrow-derived macrophages (BMMs) generated with two cytokines, macrophage colony stimulating factor (M-CSF) and granulocytic–macrophage colony stimulating factor (GM-CSF), representing anti- and proinflammatory macrophages, respectively. We quantified 6863 proteins across five time points in duplicate, comparing M-CSF (M-BMM) and GM-CSF (GM-BMM) in response to OV. We find that GM-BMMs have lower expression of key intrinsic proteins that facilitate an antiviral immune response, express higher levels of reovirus receptor protein JAM-A, and are more susceptible to oncolytic reovirus infection compared to M-BMMs. Interestingly, although M-BMMs are less susceptible to reovirus infection and subsequent cell death, they initiate an antireovirus adaptive T cell immune response comparable to that of GM-BMMs. Taken together, these data describe distinct proteome differences between these two macrophage populations in terms of their ability to mount antiviral immune responses." @default.
• W2996821602 created "2020-01-10" @default.
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• W2996821602 date "2019-12-30" @default.
• W2996821602 modified "2023-09-25" @default.
• W2996821602 title "Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells" @default.
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• W2996821602 doi "https://doi.org/10.1021/acs.jproteome.9b00583" @default.
• W2996821602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7294930" @default.
• W2996821602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31884793" @default.
• W2996821602 hasPublicationYear "2019" @default.
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