FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996836018> ?p ?o ?g. }

• W2996836018 endingPage "72" @default.
• W2996836018 startingPage "57" @default.
• W2996836018 abstract "Obesity and hyperinsulinemia are known risk factors for endometrial cancer, yet the biological pathways underlying this relationship are incompletely understood. This study investigated protein expression in endometrial cancer and benign tissue and its correlation with obesity and insulin resistance. One hundred and seven women undergoing hysterectomy for endometrial cancer or benign conditions provided a fasting blood sample and endometrial tissue. We performed proteomic expression according to body mass index, insulin resistance, and serum marker levels. We used linear regression and independent t test for statistical analysis. Proteomic data from 560 endometrial cancer cases from The Cancer Genome Atlas (TCGA) databank were used to assess reproducibility of results. One hundred and twenty seven proteins were significantly differentially expressed between 66 cancer and 26 benign patients. Protein expression involved in cell cycle progression, impacting cytoskeletal dynamics (PAK1) and cell survival (Rab 25), were most significantly altered. Obese women with cancer had increased PRAS40_pT246; a downstream marker of increased PI3K-AKT signaling. Obese women without cancer had increased mitogenic and antiapoptotic signaling by way of upregulation of Mcl-1, DUSP4, and Insulin Receptor-b. This exploratory study identified a number of candidate proteins specific to endometrioid endometrial cancer and benign endometrial tissues. Obesity and insulin resistance in women with benign endometrium leads to specific upregulation of proteins involved in insulin and driver oncogenic signaling pathways such as the PI3K-AKT-mTOR and growth factor signaling pathways which are mitogenic and also disruptive to metabolism. Obesity and hyperinsulinemia are known risk factors for endometrial cancer, yet the biological pathways underlying this relationship are incompletely understood. This study investigated protein expression in endometrial cancer and benign tissue and its correlation with obesity and insulin resistance. One hundred and seven women undergoing hysterectomy for endometrial cancer or benign conditions provided a fasting blood sample and endometrial tissue. We performed proteomic expression according to body mass index, insulin resistance, and serum marker levels. We used linear regression and independent t test for statistical analysis. Proteomic data from 560 endometrial cancer cases from The Cancer Genome Atlas (TCGA) databank were used to assess reproducibility of results. One hundred and twenty seven proteins were significantly differentially expressed between 66 cancer and 26 benign patients. Protein expression involved in cell cycle progression, impacting cytoskeletal dynamics (PAK1) and cell survival (Rab 25), were most significantly altered. Obese women with cancer had increased PRAS40_pT246; a downstream marker of increased PI3K-AKT signaling. Obese women without cancer had increased mitogenic and antiapoptotic signaling by way of upregulation of Mcl-1, DUSP4, and Insulin Receptor-b. This exploratory study identified a number of candidate proteins specific to endometrioid endometrial cancer and benign endometrial tissues. Obesity and insulin resistance in women with benign endometrium leads to specific upregulation of proteins involved in insulin and driver oncogenic signaling pathways such as the PI3K-AKT-mTOR and growth factor signaling pathways which are mitogenic and also disruptive to metabolism." @default.
• W2996836018 created "2020-01-10" @default.
• W2996836018 creator A5025321863 @default.
• W2996836018 creator A5039664461 @default.
• W2996836018 creator A5047155451 @default.
• W2996836018 creator A5063076993 @default.
• W2996836018 creator A5071446340 @default.
• W2996836018 creator A5074815814 @default.
• W2996836018 creator A5077059244 @default.
• W2996836018 date "2020-04-01" @default.
• W2996836018 modified "2023-10-15" @default.
• W2996836018 title "Proteomic analysis of malignant and benign endometrium according to obesity and insulin-resistance status using Reverse Phase Protein Array" @default.
• W2996836018 cites W1557045124 @default.
• W2996836018 cites W1560849830 @default.
• W2996836018 cites W1936675889 @default.
• W2996836018 cites W1960369368 @default.
• W2996836018 cites W1965769128 @default.
• W2996836018 cites W1971139108 @default.
• W2996836018 cites W1971398781 @default.
• W2996836018 cites W1988355907 @default.
• W2996836018 cites W1988501594 @default.
• W2996836018 cites W1993983335 @default.
• W2996836018 cites W2000739084 @default.
• W2996836018 cites W2010522003 @default.
• W2996836018 cites W2012873712 @default.
• W2996836018 cites W2013097376 @default.
• W2996836018 cites W2018033125 @default.
• W2996836018 cites W2024580654 @default.
• W2996836018 cites W2025995094 @default.
• W2996836018 cites W2036719464 @default.
• W2996836018 cites W2037914455 @default.
• W2996836018 cites W2041440766 @default.
• W2996836018 cites W2058583494 @default.
• W2996836018 cites W2068755907 @default.
• W2996836018 cites W2114031931 @default.
• W2996836018 cites W2126924946 @default.
• W2996836018 cites W2137989130 @default.
• W2996836018 cites W2139909998 @default.
• W2996836018 cites W2141662760 @default.
• W2996836018 cites W2143756124 @default.
• W2996836018 cites W2144477264 @default.
• W2996836018 cites W2147496696 @default.
• W2996836018 cites W2153383900 @default.
• W2996836018 cites W2160234571 @default.
• W2996836018 cites W2167264978 @default.
• W2996836018 cites W2167726756 @default.
• W2996836018 cites W2186857284 @default.
• W2996836018 cites W2297039980 @default.
• W2996836018 cites W2410360575 @default.
• W2996836018 cites W2418889459 @default.
• W2996836018 cites W2474625376 @default.
• W2996836018 cites W2487549822 @default.
• W2996836018 cites W2523687917 @default.
• W2996836018 cites W2526493766 @default.
• W2996836018 cites W2561389966 @default.
• W2996836018 cites W2606692456 @default.
• W2996836018 cites W2606826815 @default.
• W2996836018 cites W2760698245 @default.
• W2996836018 cites W2765520203 @default.
• W2996836018 cites W2766393670 @default.
• W2996836018 cites W2771169669 @default.
• W2996836018 cites W2781983082 @default.
• W2996836018 cites W2783930641 @default.
• W2996836018 cites W2789084287 @default.
• W2996836018 cites W2861440206 @default.
• W2996836018 cites W2954572947 @default.
• W2996836018 cites W2965589450 @default.
• W2996836018 doi "https://doi.org/10.1016/j.trsl.2019.12.003" @default.
• W2996836018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31954096" @default.
• W2996836018 hasPublicationYear "2020" @default.
• W2996836018 type Work @default.
• W2996836018 sameAs 2996836018 @default.
• W2996836018 citedByCount "7" @default.
• W2996836018 countsByYear W29968360182020 @default.
• W2996836018 countsByYear W29968360182021 @default.
• W2996836018 countsByYear W29968360182022 @default.
• W2996836018 countsByYear W29968360182023 @default.
• W2996836018 crossrefType "journal-article" @default.
• W2996836018 hasAuthorship W2996836018A5025321863 @default.
• W2996836018 hasAuthorship W2996836018A5039664461 @default.
• W2996836018 hasAuthorship W2996836018A5047155451 @default.
• W2996836018 hasAuthorship W2996836018A5063076993 @default.
• W2996836018 hasAuthorship W2996836018A5071446340 @default.
• W2996836018 hasAuthorship W2996836018A5074815814 @default.
• W2996836018 hasAuthorship W2996836018A5077059244 @default.
• W2996836018 hasBestOaLocation W29968360182 @default.
• W2996836018 hasConcept C104317684 @default.
• W2996836018 hasConcept C112446052 @default.
• W2996836018 hasConcept C121608353 @default.
• W2996836018 hasConcept C126322002 @default.
• W2996836018 hasConcept C127561419 @default.
• W2996836018 hasConcept C134018914 @default.
• W2996836018 hasConcept C143998085 @default.
• W2996836018 hasConcept C2777088508 @default.
• W2996836018 hasConcept C2777391703 @default.
• W2996836018 hasConcept C2779306644 @default.
• W2996836018 hasConcept C2780988686 @default.
• W2996836018 hasConcept C502942594 @default.

• next