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- W2996852834 abstract "Abstract Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. While it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. Here, we sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. This divergence date represents the earliest possible date for the establishment of measles in human populations. Our analyses show that the measles virus potentially arose as early as the 4 th century BCE, rekindling the recently challenged hypothesis of an antique origin of this disease. One Sentence Summary Measles virus diverged from rinderpest virus in the 4 th century BCE, which is compatible with an emergence of measles during Antiquity." @default.
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- W2996852834 date "2019-12-30" @default.
- W2996852834 modified "2023-10-16" @default.
- W2996852834 title "The history of measles: from a 1912 genome to an antique origin" @default.
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- W2996852834 doi "https://doi.org/10.1101/2019.12.29.889667" @default.
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