Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996859094> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2996859094 abstract "Abstract We see affordability as a key challenge in making organs-on-chips accessible to a wider range of users, particularly outside the highest-resource environments. Here, we present an approach to barrier-on-a-chip fabrication based on double-sided pressure-sensitive adhesive tape and off-the-shelf polycarbonate. Besides a low materials cost, common also to PDMS or thermoplastics, it requires minimal (€ 100) investment in laboratory equipment, yet at the same time is suitable for upscaling to industrial roll-to-roll manufacture. We evaluate our microhpysiological system with an epithelial (C2BBe1) barrier model of the small intestine, studying the biological effects of permeable support pore size, as well as stimulation with a common food compound (chili pepper-derived capsaicinoids). The cells form tight and continuous barrier layers inside our systems, with comparable permeability but superior epithelial polarization compared to Transwell culture, in line with other perfused microphysiological models. Permeable support pore size is shown to weakly impact barrier layer integrity as well as the metabolic cell profile. Capsaicinoid response proves distinct between culture systems, but we show that impacted metabolic pathways are partly conserved, and that cytoskeletal changes align with previous studies. Overall, our tape-based microphysiolgical system proves to be a robust and reproducible approach to studying physiological barriers, in spite of its low cost." @default.
- W2996859094 created "2020-01-10" @default.
- W2996859094 creator A5023344432 @default.
- W2996859094 creator A5050716624 @default.
- W2996859094 creator A5059036177 @default.
- W2996859094 creator A5064813016 @default.
- W2996859094 creator A5071769240 @default.
- W2996859094 date "2020-01-06" @default.
- W2996859094 modified "2023-10-01" @default.
- W2996859094 title "Low-cost microphysiological systems: Feasibility study of a tape-based barrier-on-chip system for small intestine modeling" @default.
- W2996859094 cites W1574298606 @default.
- W2996859094 cites W1592976485 @default.
- W2996859094 cites W1961194530 @default.
- W2996859094 cites W2002437040 @default.
- W2996859094 cites W2002720167 @default.
- W2996859094 cites W2013520568 @default.
- W2996859094 cites W2015195193 @default.
- W2996859094 cites W2034016148 @default.
- W2996859094 cites W2035505537 @default.
- W2996859094 cites W2041812399 @default.
- W2996859094 cites W2045247602 @default.
- W2996859094 cites W2046827775 @default.
- W2996859094 cites W2047050656 @default.
- W2996859094 cites W2063727717 @default.
- W2996859094 cites W2065062437 @default.
- W2996859094 cites W2072755794 @default.
- W2996859094 cites W2073939393 @default.
- W2996859094 cites W2075519188 @default.
- W2996859094 cites W2078449435 @default.
- W2996859094 cites W2080046774 @default.
- W2996859094 cites W2081465448 @default.
- W2996859094 cites W2090157239 @default.
- W2996859094 cites W2098429882 @default.
- W2996859094 cites W2106064607 @default.
- W2996859094 cites W2118762743 @default.
- W2996859094 cites W2125936195 @default.
- W2996859094 cites W2134855199 @default.
- W2996859094 cites W2167279371 @default.
- W2996859094 cites W2168752825 @default.
- W2996859094 cites W2273159739 @default.
- W2996859094 cites W2284114956 @default.
- W2996859094 cites W2308070823 @default.
- W2996859094 cites W2333671040 @default.
- W2996859094 cites W2765495601 @default.
- W2996859094 cites W2777235740 @default.
- W2996859094 cites W2788619673 @default.
- W2996859094 cites W2794458190 @default.
- W2996859094 cites W2803084733 @default.
- W2996859094 cites W2803664483 @default.
- W2996859094 cites W2804928201 @default.
- W2996859094 cites W2885351238 @default.
- W2996859094 cites W2886103315 @default.
- W2996859094 cites W2886738588 @default.
- W2996859094 cites W2917576966 @default.
- W2996859094 cites W2922805334 @default.
- W2996859094 cites W2943483885 @default.
- W2996859094 cites W2947707033 @default.
- W2996859094 cites W2976634454 @default.
- W2996859094 cites W563195749 @default.
- W2996859094 doi "https://doi.org/10.1101/2020.01.06.894147" @default.
- W2996859094 hasPublicationYear "2020" @default.
- W2996859094 type Work @default.
- W2996859094 sameAs 2996859094 @default.
- W2996859094 citedByCount "0" @default.
- W2996859094 crossrefType "posted-content" @default.
- W2996859094 hasAuthorship W2996859094A5023344432 @default.
- W2996859094 hasAuthorship W2996859094A5050716624 @default.
- W2996859094 hasAuthorship W2996859094A5059036177 @default.
- W2996859094 hasAuthorship W2996859094A5064813016 @default.
- W2996859094 hasAuthorship W2996859094A5071769240 @default.
- W2996859094 hasBestOaLocation W29968590941 @default.
- W2996859094 hasConcept C171250308 @default.
- W2996859094 hasConcept C177779419 @default.
- W2996859094 hasConcept C192562407 @default.
- W2996859094 hasConcept C41008148 @default.
- W2996859094 hasConcept C86803240 @default.
- W2996859094 hasConcept C95444343 @default.
- W2996859094 hasConceptScore W2996859094C171250308 @default.
- W2996859094 hasConceptScore W2996859094C177779419 @default.
- W2996859094 hasConceptScore W2996859094C192562407 @default.
- W2996859094 hasConceptScore W2996859094C41008148 @default.
- W2996859094 hasConceptScore W2996859094C86803240 @default.
- W2996859094 hasConceptScore W2996859094C95444343 @default.
- W2996859094 hasLocation W29968590941 @default.
- W2996859094 hasOpenAccess W2996859094 @default.
- W2996859094 hasPrimaryLocation W29968590941 @default.
- W2996859094 hasRelatedWork W10649126 @default.
- W2996859094 hasRelatedWork W11214628 @default.
- W2996859094 hasRelatedWork W11986917 @default.
- W2996859094 hasRelatedWork W1261651 @default.
- W2996859094 hasRelatedWork W3423763 @default.
- W2996859094 hasRelatedWork W367135 @default.
- W2996859094 hasRelatedWork W6336564 @default.
- W2996859094 hasRelatedWork W7631309 @default.
- W2996859094 hasRelatedWork W8790197 @default.
- W2996859094 hasRelatedWork W9400695 @default.
- W2996859094 isParatext "false" @default.
- W2996859094 isRetracted "false" @default.
- W2996859094 magId "2996859094" @default.
- W2996859094 workType "article" @default.