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• W299686778 abstract "Breast Cancer and Its Precursor Lesions: Making Sense and Making It Early Editor: Patricia A. Thomas. Contributors: Joan Cangiarella, Fang Fan, Patricia A. Thomas. Breast Cancer and Its Precursor Lesions: Making Sense and Making It Early. New York: Humana Press; 2011 . ISBN 978-1-58829-686-3Breast cancer is the most common cause of death in women worldwide. Breast cancer treatment involves surgery, radiotherapy, chemotherapy, and hormonal therapy in different therapeutic regimens. Pathologists play a crucial role in the diagnosis and management of disease enabling other specialists to select the best therapeutic regimen for an individual breast cancer patient. However, it is often difficult to understand and interpret pathology reports and recommendations for surgeons, oncologists and scientists. Knowledge and better understanding of pathologic assessment techniques as well as behaviour of cancerous and precancerous breast diseases may lead to more complex pathology reports and then better diagnosis and management of breast cancer therapy. The book covers the common breast cancer conditions and diseases and is very helpful to non-pathologists like clinicians, surgeons, residents, scientists, and even patients to better understand the pathology reports and diagnosis of breast cancer. The text is divided into seven chapters describing the pathologic conditions of the breast, diseases, and how to read and write pathology reports. All chapters are supplemented by illustrations, tables and sufficient amount of references. All contributors to this book are highly regarded experts in pathology and laboratory medicine.Chapter 1: Overview by Patricia A. ThomasThe first chapter presents basic data and information on breast cancer incidence, epidemiology and risk factors associated with breast cancer as well as prognostic and predictive factors used in clinical practise (e.g. racial differences). Prognostic and predictive markers are described although microarray systems (MammaPrint, Oncotype DX) identifying genetic markers are not mentioned.Chapter 2: Common benign conditions of low concern by Fang Fan and Patricia A. ThomasThis chapter is devoted to benign breast conditions. It briefly describes breast structure and the anatomy of glands (lobules and ducts). Benign abnormalities are divided into two categories: a group with no risk for developing breast cancer, such as acute mastitis, subareolar abscess, mammary duct ectasia, fat necrosis or lymphocytic mastopathy/diabetic mastopathy and nonproliferative fibrocystic changes; and a group with increased risk of developing breast cancer. Attached figures demonstrate mentioned benign abnormalities. Finally, it contains interpretation of pathology reports describing the structural abnormalities of breast samples seen by microscope. In reports, type of samples is stated and microcalcifications are identified.Chapter 3: Benign conditions associated with a risk for the subsequent development of cancer by Patricia A. ThomasIn the third chapter, general breast abnormalities associated with risk of breast cancer development are described and illustrated. Communication and collaboration between pathologists, radiologists and clinicians is necessary for successful evaluation and determination of the importance of pathology findings in prognosis and prediction of breast cancer therapy. The pathology report should be straightforward and it should involve description of microcalcification status, proliferative lesions and atypical hyperplasia of any kind associated with increased risk of breast cancer.Chapter 4: Precursor lesions and non-invasive cancers by Joan Cangiarella and Fang FanChapter 4 gives a detailed description of the lobular neoplasia diagnosis. Lobular neoplasia includes atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). The distinction between ALH and LCIS is based on the extent of epithelial proliferation. …" @default.
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