FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996887305> ?p ?o ?g. }

• W2996887305 endingPage "162" @default.
• W2996887305 startingPage "147" @default.
• W2996887305 abstract "Animal models consisting of inbred laboratory rodent strains have been a powerful tool for decades, helping to unravel the underpinnings of biological problems and employed to evaluate potential therapeutic treatments in drug discovery. While inbred strains demonstrate relatively reliable and predictable responses, using a single inbred strain alone or as a background to a mutation is analogous to running a clinical trial in a single individual and their identical twins. Indeed, complex etiologies drive the most common human diseases, and a single inbred strain that is a surrogate of a single genome, or data generated from a single sex, is not representative of the genetically diverse patient populations. Further, pharmacological and toxicology data generated in otherwise healthy animals may not translate to disease states where physiology, metabolism, and general health are compromised. The purpose of this chapter is to provide guidance for improving generalizability of preclinical studies by providing insight into necessary considerations for introducing systematic variation within the study design, such as genetic diversity, the use of both sexes, and selection of appropriate age and disease model. The outcome of implementing these considerations should be that reproducibility and generalizability of significant results are significantly enhanced leading to improved clinical translation." @default.
• W2996887305 created "2020-01-10" @default.
• W2996887305 creator A5013927797 @default.
• W2996887305 creator A5054219325 @default.
• W2996887305 creator A5074035943 @default.
• W2996887305 date "2019-01-01" @default.
• W2996887305 modified "2023-09-26" @default.
• W2996887305 title "Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies" @default.
• W2996887305 cites W1552728147 @default.
• W2996887305 cites W1557131785 @default.
• W2996887305 cites W1968825227 @default.
• W2996887305 cites W1971510748 @default.
• W2996887305 cites W1973003238 @default.
• W2996887305 cites W1978444428 @default.
• W2996887305 cites W1982818125 @default.
• W2996887305 cites W1984920442 @default.
• W2996887305 cites W1986723837 @default.
• W2996887305 cites W1989487884 @default.
• W2996887305 cites W1996579832 @default.
• W2996887305 cites W1997538585 @default.
• W2996887305 cites W2003921075 @default.
• W2996887305 cites W2005501593 @default.
• W2996887305 cites W2009128308 @default.
• W2996887305 cites W2020738884 @default.
• W2996887305 cites W2023825621 @default.
• W2996887305 cites W2027431314 @default.
• W2996887305 cites W2029336069 @default.
• W2996887305 cites W2037250268 @default.
• W2996887305 cites W2040831152 @default.
• W2996887305 cites W2041384370 @default.
• W2996887305 cites W2042265914 @default.
• W2996887305 cites W2044038526 @default.
• W2996887305 cites W2047706200 @default.
• W2996887305 cites W2050091356 @default.
• W2996887305 cites W2052317102 @default.
• W2996887305 cites W2058867803 @default.
• W2996887305 cites W2061665487 @default.
• W2996887305 cites W2065679303 @default.
• W2996887305 cites W2089799315 @default.
• W2996887305 cites W2090869890 @default.
• W2996887305 cites W2109276098 @default.
• W2996887305 cites W2118247434 @default.
• W2996887305 cites W2122538288 @default.
• W2996887305 cites W2146249493 @default.
• W2996887305 cites W2146568686 @default.
• W2996887305 cites W2155286781 @default.
• W2996887305 cites W2156710869 @default.
• W2996887305 cites W2161000333 @default.
• W2996887305 cites W2170096831 @default.
• W2996887305 cites W2171921570 @default.
• W2996887305 cites W2232091047 @default.
• W2996887305 cites W2398472827 @default.
• W2996887305 cites W2487634804 @default.
• W2996887305 cites W2511828599 @default.
• W2996887305 cites W2527688481 @default.
• W2996887305 cites W2582553117 @default.
• W2996887305 cites W2587104373 @default.
• W2996887305 cites W2624657184 @default.
• W2996887305 cites W2648952709 @default.
• W2996887305 cites W2671308999 @default.
• W2996887305 cites W2787981664 @default.
• W2996887305 cites W2792726499 @default.
• W2996887305 cites W2952728789 @default.
• W2996887305 cites W4234812465 @default.
• W2996887305 cites W4296816736 @default.
• W2996887305 cites W49968849 @default.
• W2996887305 cites W73990037 @default.
• W2996887305 doi "https://doi.org/10.1007/164_2019_282" @default.
• W2996887305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31595415" @default.
• W2996887305 hasPublicationYear "2019" @default.
• W2996887305 type Work @default.
• W2996887305 sameAs 2996887305 @default.
• W2996887305 citedByCount "8" @default.
• W2996887305 countsByYear W29968873052020 @default.
• W2996887305 countsByYear W29968873052022 @default.
• W2996887305 countsByYear W29968873052023 @default.
• W2996887305 crossrefType "book-chapter" @default.
• W2996887305 hasAuthorship W2996887305A5013927797 @default.
• W2996887305 hasAuthorship W2996887305A5054219325 @default.
• W2996887305 hasAuthorship W2996887305A5074035943 @default.
• W2996887305 hasBestOaLocation W29968873051 @default.
• W2996887305 hasConcept C104317684 @default.
• W2996887305 hasConcept C138496976 @default.
• W2996887305 hasConcept C142724271 @default.
• W2996887305 hasConcept C15744967 @default.
• W2996887305 hasConcept C27158222 @default.
• W2996887305 hasConcept C2779134260 @default.
• W2996887305 hasConcept C54355233 @default.
• W2996887305 hasConcept C60644358 @default.
• W2996887305 hasConcept C70721500 @default.
• W2996887305 hasConcept C71924100 @default.
• W2996887305 hasConcept C76725341 @default.
• W2996887305 hasConcept C86803240 @default.
• W2996887305 hasConceptScore W2996887305C104317684 @default.
• W2996887305 hasConceptScore W2996887305C138496976 @default.
• W2996887305 hasConceptScore W2996887305C142724271 @default.
• W2996887305 hasConceptScore W2996887305C15744967 @default.
• W2996887305 hasConceptScore W2996887305C27158222 @default.

• next