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- W2996900752 abstract "Background: Despite publications are still scarce, preoperative immuno-nutrition (PIN) in patients undergoing pancreatectomy seems to be effective, even in well-nourished ones. Aim: to compare post-pancreatectomy outcomes in two groups of patients with and without PIN. Methods: Prospective non-randomized study. Complications and length of stay (LOS) after major pancreatectomy were compared between 10 patients who received oral PIN (Impact®, Nestlé, 7 days prior to surgery, irrespective of nutritional status) and 23 control patients (CP). Study period January 2015-December 2016. Subgroup analysis according to high-risk category of PREPARE score. Statistics: SPSS 18. Results: Sex: 60.6% males, age: 62±11.1 years old, BMI: 25.6±4.1 Kg/m2 (no differences between groups). Neither complications rates (Clavien ≥III morbidity, post-pancreatectomy specific complications, wound infection) nor LOS showed statistical differences. However, there was a trend to fewer hemorrhage cases in PIN (10% vs 26%, p=0,4). Subgroup analysis in high-risk patients (3 PIN vs 7 CP, no differences in sex, age and BMI): PIN presented non-statistical fewer rates of Clavien ≥III morbidity (33.3% vs 71.4%), gastroparesis (33.3% vs 66.7%), fistula (0% vs 28.6%), hemorrhage (0% vs 57.1%) and wound infection (0% vs 28.6%). Conclusion: PIN has not improved outcomes, though there is a trend to fewer complications particularly in high-risk patients according to PREPARE score. Enlarging sample size of PIN patients may probably obtain statistical favourable Results. References: [25243549] Uzunoglu FG1, Reeh M, Vettorazzi E, Ruschke T, Hannah P, Nentwich MF, Vashist YK, Bogoevski D, König A, Janot M, Gavazzi F, Zerbi A, Todaro V, Malleo G, Uhl W, Montorsi M, Bassi C, Izbicki JR, Bockhorn M., (2014), Preoperative Pancreatic Resection (PREPARE) score: a prospective multicenter-based morbidity risk score." @default.
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- W2996900752 date "2019-01-01" @default.
- W2996900752 modified "2023-10-16" @default.
- W2996900752 title "Effects of preoperative immunonutrition on surgical outcomes after major pancreatic resections: a non-randomized controlled analysis" @default.
- W2996900752 doi "https://doi.org/10.1016/j.hpb.2019.10.1221" @default.
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