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- W2996975917 abstract "Abstract Reward associations during auditory learning induce cortical plasticity in the primary auditory cortex. A prominent source of such influence is the ventral tegmental area (VTA), which conveys a dopaminergic teaching signal to the primary auditory cortex. Yet, it is unknown, how the VTA influences cortical frequency processing and spectral integration. Therefore, we investigated the temporal effects of direct optogenetic stimulation of the VTA onto spectral integration in the auditory cortex on a synaptic circuit level by current-source-density analysis in anesthetized Mongolian gerbils. While auditory lemniscal input predominantly terminates in the granular input layers III/IV, we found that VTA-mediated modulation of spectral processing is relayed by a different circuit, namely enhanced thalamic inputs to the infragranular layers Vb/VIa. Activation of this circuit yields a frequency-specific gain amplification of local sensory input and enhances corticocortical information transfer, especially in supragranular layers I/II. This effects persisted over more than 30 minutes after VTA stimulation. Altogether, we demonstrate that the VTA exhibits a long-lasting influence on sensory cortical processing via infragranular layers transcending the signaling of a mere reward-prediction error. We thereby demonstrate a cellular and circuit substrate for the influence of reinforcement-evaluating brain systems on sensory processing in the auditory cortex." @default.
- W2996975917 created "2020-01-10" @default.
- W2996975917 creator A5014313028 @default.
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- W2996975917 date "2019-12-31" @default.
- W2996975917 modified "2023-10-03" @default.
- W2996975917 title "Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex" @default.
- W2996975917 cites W1549813206 @default.
- W2996975917 cites W1592304224 @default.
- W2996975917 cites W1595012730 @default.
- W2996975917 cites W1912996233 @default.
- W2996975917 cites W1944839424 @default.
- W2996975917 cites W1966253466 @default.
- W2996975917 cites W1969361316 @default.
- W2996975917 cites W1970226919 @default.
- W2996975917 cites W1971690948 @default.
- W2996975917 cites W1973371295 @default.
- W2996975917 cites W1983531475 @default.
- W2996975917 cites W1987521590 @default.
- W2996975917 cites W1997896450 @default.
- W2996975917 cites W1999407810 @default.
- W2996975917 cites W2003367821 @default.
- W2996975917 cites W2006364660 @default.
- W2996975917 cites W2008275505 @default.
- W2996975917 cites W2012848446 @default.
- W2996975917 cites W2013943363 @default.
- W2996975917 cites W2019402390 @default.
- W2996975917 cites W2024680557 @default.
- W2996975917 cites W2025766482 @default.
- W2996975917 cites W2030903788 @default.
- W2996975917 cites W2036483999 @default.
- W2996975917 cites W2037060024 @default.
- W2996975917 cites W2039912069 @default.
- W2996975917 cites W2040076236 @default.
- W2996975917 cites W2041918412 @default.
- W2996975917 cites W2050932531 @default.
- W2996975917 cites W2055354313 @default.
- W2996975917 cites W2062192993 @default.
- W2996975917 cites W2063301572 @default.
- W2996975917 cites W2064437385 @default.
- W2996975917 cites W2076457657 @default.
- W2996975917 cites W2081283090 @default.
- W2996975917 cites W2082013844 @default.
- W2996975917 cites W2087369617 @default.
- W2996975917 cites W2089242029 @default.
- W2996975917 cites W2092094256 @default.
- W2996975917 cites W2110665798 @default.
- W2996975917 cites W2111736228 @default.
- W2996975917 cites W2115249492 @default.
- W2996975917 cites W2128284302 @default.
- W2996975917 cites W2128835192 @default.
- W2996975917 cites W2129785364 @default.
- W2996975917 cites W2131472234 @default.
- W2996975917 cites W2132363607 @default.
- W2996975917 cites W2134330719 @default.
- W2996975917 cites W2136431242 @default.
- W2996975917 cites W2143051737 @default.
- W2996975917 cites W2146357663 @default.
- W2996975917 cites W2147154507 @default.
- W2996975917 cites W2149736796 @default.
- W2996975917 cites W2151934707 @default.
- W2996975917 cites W2168497148 @default.
- W2996975917 cites W2185598055 @default.
- W2996975917 cites W2187840837 @default.
- W2996975917 cites W2190199438 @default.
- W2996975917 cites W2200797417 @default.
- W2996975917 cites W2252729124 @default.
- W2996975917 cites W2255302334 @default.
- W2996975917 cites W2284417188 @default.
- W2996975917 cites W2290106507 @default.
- W2996975917 cites W2410084590 @default.
- W2996975917 cites W2413165212 @default.
- W2996975917 cites W2507560271 @default.
- W2996975917 cites W2515285711 @default.
- W2996975917 cites W2558867581 @default.
- W2996975917 cites W2747279431 @default.
- W2996975917 cites W2792330332 @default.
- W2996975917 cites W2799634418 @default.
- W2996975917 cites W2808304326 @default.
- W2996975917 cites W2811286972 @default.
- W2996975917 cites W2888802596 @default.
- W2996975917 cites W2892887172 @default.
- W2996975917 cites W2901276374 @default.
- W2996975917 cites W2902272440 @default.
- W2996975917 cites W2950200460 @default.
- W2996975917 cites W2952426443 @default.
- W2996975917 cites W2965439919 @default.
- W2996975917 cites W4242770316 @default.
- W2996975917 cites W2569500008 @default.
- W2996975917 doi "https://doi.org/10.1038/s41598-019-56926-6" @default.
- W2996975917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6938496" @default.
- W2996975917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31892726" @default.
- W2996975917 hasPublicationYear "2019" @default.
- W2996975917 type Work @default.